Results 21 to 30 of about 77,663 (255)
Immunomodulatory Activities of Small Host Defense Peptides [PDF]
Antimicrobial Agents and Chemotherapy, 2005 ABSTRACT Recent studies have demonstrated that in addition to their antimicrobial activity, cationic host defense peptides, like the human cathelicidin LL-37, perform many activities relating to innate immunity, including the induction or modulation of chemokine and cytokine production, alteration of gene expression in host cells,
Bowdish, Dawn M E +3 more
openaire +4 more sources
Host Defense Peptides in Wound Healing
Molecular Medicine, 2008 Host defense peptides are effector molecules of the innate immune system. They show broad antimicrobial action against gram-positive and -negative bacteria, and they likely play a key role in activating and mediating the innate as well as adaptive immune response in infection and inflammation. These features make them of high interest for wound healing
Lars, Steinstraesser +9 more
openaire +3 more sources
Regulation of the intestinal barrier function by host defense peptides
Frontiers in Veterinary Science, 2015 Intestinal barrier function is achieved primarily through regulating the synthesis of mucins and tight junction proteins, which are critical for maintaining optimal gut health and animal performance.
Kelsy eRobinson +4 more
doaj +4 more sources
Oncolytic Activities of Host Defense Peptides [PDF]
International Journal of Molecular Sciences, 2011 Cancer continues to be a leading source of morbidity and mortality worldwide in spite of progress in oncolytic therapies. In addition, the incidence of cancers affecting the breast, kidney, prostate and skin among others continue to rise. Chemotherapeutic drugs are widely used in cancer treatment but have the serious drawback of nonspecific toxicity ...
Benna, Sammy al- +3 more
core +5 more sources
The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production [PDF]
Veterinary Research, 2018 Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and ...
Albert van Dijk +3 more
doaj +3 more sources
Evaluating Host Defense Peptides: A Comparative Analysis of Synthetic Peptides and Recombinant Concatemers [PDF]
BiomoleculesThe global antibiotic resistance crisis raises concerns about antibiotic use, and alternative strategies are urgently needed. In this context, host defense peptides (HDPs) have rapidly gained interest.
Cristina Saubi +6 more
doaj +2 more sources
Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity.
PLoS ONE, 2014 Cationic, amphipathic host defense peptides represent a promising group of agents to be developed for anticancer applications. Poly-N-substituted glycines, or peptoids, are a class of biostable, peptidomimetic scaffold that can display a great diversity ...
Wei Huang +6 more
doaj +2 more sources
Crosstalk Between Intestinal Microbiota and Host Defense Peptides in Fish [PDF]
BiologyThe intricate crosstalk between intestinal microbiota and host defense peptides (HDPs) in aquaculture has emerged as a cornerstone for advancing sustainable disease management and reducing reliance on antibiotics. This review synthesizes current insights
Xiao-Zheng Yu, Yang Yu, Zi-Yan Liu
doaj +2 more sources
Agronomy, 2022 Host-defense peptides (HDP) are emerging as promising phytosanitaries due to their potency, low plant, animal and environmental toxicity, and above all, low induction of antimicrobial resistance.
Fernando Lobo, Alicia Boto
doaj +3 more sources
Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and Pseudomonas aeruginosa sepsis. [PDF]
PLoS ONE, 2012 Gram-negative sepsis is accompanied by a disproportionate innate immune response and excessive coagulation mainly induced by endotoxins released from bacteria. Due to rising antibiotic resistance and current lack of other effective treatments there is an
Martina Kalle +8 more
doaj +3 more sources