Results 21 to 30 of about 145,208 (274)
Host Defense Peptides from Asian Frogs as Potential Clinical Therapies
Antibiotics, 2015 Host defense peptides (HDPs) are currently major focal points of medical research as infectious microbes are gaining resistance to existing drugs. They are effective against multi-drug resistant pathogens due to their unique primary target, biological ...
Vineeth T.V. Kumar +3 more
doaj +3 more sources
Avian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications
Pharmaceuticals, 2014 Host defense peptides (HDPs) are an important first line of defense with antimicrobial and immunomoduatory properties. Because they act on the microbial membranes or host immune cells, HDPs pose a low risk of triggering microbial resistance and therefore,
Guolong Zhang, Lakshmi T. Sunkara
doaj +3 more sources
Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis
Brazilian Journal of Oral Sciences, 2021 Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated
Ingrid Aquino Amorim +6 more
doaj +1 more source
Molecules, 2023 Antimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years, as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemic ...
Caroline Donaghy +4 more
doaj +1 more source
Novel African trypanocidal agents: membrane rigidifying peptides [PDF]
, 2012 The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased ...
Andreas Hartel +8 more
core +14 more sources
Oncolytic Activities of Host Defense Peptides [PDF]
International Journal of Molecular Sciences, 2011 Cancer continues to be a leading source of morbidity and mortality worldwide in spite of progress in oncolytic therapies. In addition, the incidence of cancers affecting the breast, kidney, prostate and skin among others continue to rise. Chemotherapeutic drugs are widely used in cancer treatment but have the serious drawback of nonspecific toxicity ...
Benna, Sammy al- +3 more
openaire +3 more sources
Microbiology Spectrum, 2022 Klebsiella pneumoniae produces a thick capsule layer composed of extracellular polysaccharides protecting the bacterial cells from clearance by innate host immunity during infection.
Renee M. Fleeman, Bryan W. Davies
doaj +1 more source
Proteolysis of human thrombin generates novel host defense peptides. [PDF]
PLoS Pathogens, 2010 The coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of fibrinogen into fibrin, and formation of a fibrin clot.
Praveen Papareddy +7 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 The burgeoning menace of antimicrobial resistance across the globe has necessitated investigations into other chemotherapeutic strategies to combat infections.
Sukriyo Chakraborty +2 more
doaj +1 more source
Antimicrobial peptides: agents of border protection for companion animals. [PDF]
, 2012 Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis.
Affolter, Verena K +2 more
core +1 more source