Results 21 to 30 of about 2,543,243 (267)
Epithelial antimicrobial peptides in host defense against infection [PDF]
Respiratory Research, 2000 One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs.
Bals Robert
doaj +2 more sources
Human and Marine Host Defense Peptides for Healthy Skin [PDF]
Marine DrugsThe skin serves as the first line barrier of innate immunity, protecting the body from external influences and maintaining its homeostasis. Exogenous and endogenous stress factors alter the structure and functional properties of the skin.
Svetlana V. Guryanova +2 more
doaj +2 more sources
The Therapeutic Potential of Host-Defense Antimicrobial Peptides
Current Drug Targets, 2002 Species across the evolutionary scale from insects to mammals deploy peptides to counter microbial invaders. Although, there are considerable differences in the primary and secondary structures of these peptides, they exert their antimicrobial activity by common mechanisms ie. by membrane permeabilization. Extensive structure-function studies have been
N, Sitaram, R, Nagaraj
core +4 more sources
Host Defense Peptides as Templates for Antifungal Drug Development [PDF]
Journal of Fungi, 2020 Current treatment for invasive fungal diseases is limited to three classes of antifungal drugs: azoles, polyenes, and echinocandins. The most recently introduced antifungal class, the echinocandins, was first approved nearly 30 years ago.
Virginia Basso +3 more
doaj +2 more sources
Antibiotics, 2020 As natural host defense compounds produced by numerous prokaryotic and eukaryotic life forms, antimicrobial peptides (AMPs) are now emerging as solid candidate chemotherapeutic drugs to fight against the various types of pathogenic Gram-positive and Gram-
Jean-Marc Sabatier
doaj +2 more sources
Evaluating Host Defense Peptides: A Comparative Analysis of Synthetic Peptides and Recombinant Concatemers [PDF]
BiomoleculesThe global antibiotic resistance crisis raises concerns about antibiotic use, and alternative strategies are urgently needed. In this context, host defense peptides (HDPs) have rapidly gained interest.
Cristina Saubi +6 more
doaj +2 more sources
The Antimicrobial and Host Defense Peptides of Drosophila melanogaster [PDF]
Annual Review of MicrobiologyDrosophila fruit flies are a powerful model for studying innate immunity. In Drosophila , seven classical antimicrobial peptide (AMP) gene families were identified in the 1990s. These genes are primarily regulated by the TOLL and IMD NF-κB pathways in response to infection.
Hanson, Mark A. +3 more
openaire +4 more sources
Expression and Function of Host Defense Peptides at Inflammation Sites. [PDF]
Int J Mol Sci, 2019 There is a growing interest in the complex role of host defense peptides (HDPs) in the pathophysiology of several immune-mediated inflammatory diseases. The physicochemical properties and selective interaction of HDPs with various receptors define their immunomodulatory effects. However, it is quite challenging to understand their function because some
Prasad SV +4 more
europepmc +5 more sources
Induction of Chicken Host Defense Peptides within Disease-Resistant and -Susceptible Lines. [PDF]
Genes (Basel), 2020 Host defense peptides (HDPs) are multifunctional immune molecules that respond to bacterial and viral pathogens. In the present study, bone marrow-derived cells (BMCs) and chicken embryonic fibroblasts (CEFs) were cultured from a Leghorn line (Ghs6) and ...
Jang HJ, Monson M, Kaiser M, Lamont SJ.
europepmc +2 more sources
Host Defense Peptides in the Oral Cavity
, 2008 Publisher Summary Host defense peptides (HDPs) are important in defense of tissues throughout the human mouth. Like resident microbial populations, HDPs are diverse, species-specific, and site-specific, and they have evolved in response to selection pressures exerted by resident and pathogenic microbial populations.
Devine, Deirdre, Cosseau, Celine
openaire +3 more sources