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Advancements in Host-Based Interventions for Influenza Treatment
Influenza is a major acute respiratory infection that causes mortality and morbidity worldwide. Two classes of conventional antivirals, M2 ion channel blockers and neuraminidase inhibitors, are mainstays in managing influenza disease to lessen symptoms ...
Tsz-Fung Yip +3 more
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Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses
Viruses are dependent on host factors at all parts of the infection cycle, such as translation, genome replication, encapsidation, and cell-to-cell and systemic movement.
Rosalba Rodriguez-Peña +2 more
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Macaque monkeys serve as important animal models for understanding the pathogenesis of lentiviral infections. Since human immunodeficiency virus type 1 (HIV-1) hardly replicates in macaque cells, simian immunodeficiency virus (SIV) or chimeric viruses ...
Akatsuki eSaito +2 more
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Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress
Hepatitis delta virus (HDV) is the smallest known human virus and causes the most severe form of human viral hepatitis, yet it is still not fully understood how the virus replicates and how it interacts with many host proteins during replication.
Susannah Stephenson-Tsoris +1 more
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PA and PA-X: two key proteins from segment 3 of the influenza viruses
In recent years, the influenza viruses have posed an increasingly severe threat to public health. It is essential to analyze the virulence and pathogenesis of influenza viruses to prevent and control them, as well as create antiviral drugs.
Xin Zhang +10 more
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To complete their replication cycle, retroviruses need to integrate a DNA copy of their RNA genome into a host chromosome. Integration site selection is not random and is driven by multiple viral and cellular host factors specific to different classes of
Eline Pellaers +3 more
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Current perspectives on alphavirus encapsidation, assembly and budding
Alphaviruses are an escalating global concern due to their considerable clinical impact and expanding geographic distribution. Transmitted primarily through the bites of infected mosquitoes, alphaviruses cause a wide spectrum of arthritogenic and ...
Kanchan Bhardwaj +4 more
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Host and environment are key factors: Figure 1 [PDF]
On 5 July 2003, the WHO removed Taiwan from its list of areas with recent local transmission of SARS meaning that all known chains of person to person transmission of the severe acute respiratory syndrome (SARS) virus have now been broken.1 However, the WHO executive director for communicable diseases advised that public health should not let down its ...
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The role of host genetic factors and host immunity in necrotic enteritis [PDF]
The increasing number of legislative restrictions and the voluntary withdrawal of antibiotic growth promoters worldwide will continue to impact poultry health and production. The rising incidence of Clostridium infections and development of necrotic enteritis (NE) in commercial chickens has been associated with the withdrawal of antibiotics.
Sung T, Oh, Hyun S, Lillehoj
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Staphylococcal Infections: Host and Pathogenic Factors [PDF]
In 1880, the Scottish surgeon Sir Alexander Ogston first described staphylococci in pus from a surgical abscess in a knee joint: “The masses looked like bunches of grapes” [...]
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