Results 71 to 80 of about 1,082,353 (268)

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model

Frontiers in Microbiology, 2019
BackgroundAggregatibacter actinomycetemcomitans, a periodontal pathogen, secretes a cytolethal distending toxin (AaCDT) that causes host cell cycle arrest and cell death.
Siriyod Denmongkholchai, Siriyod Denmongkholchai, Prashant Katare, Prashant Katare, Sarocha Choochuay, Panida Thanyasrisung, Keiko Tsuruda, Motoyuki Sugai, Motoyuki Sugai, Skorn Mongkolsuk, Oranart Matangkasombut, Oranart Matangkasombut   +11 more
doaj   +1 more source

Change of host range in a resistance factor

Genetical Research, 1970
SUMMARYAn R factor for ampicillin and streptomycin resistance (AS) was identified inSalmonella enteritidis. The AS factor transferred freely toEscherichia coliK12, but only two of 260 K12(AS) clones from this cross would transfer AS toS. typhimurium, although all lines tested transferred it toS. enteritidisand K12. A study of one of the two exceptional
E S, Anderson, E J, Threlfall
openaire   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Host Genetic Determinants of SARS-CoV-2 Susceptibility in Transplant Recipients and Donor Candidates: A Multicohort Analysis of HLA Variation

Biomedicines
Background: Host genetic variation plays a key role in susceptibility to SARS-CoV-2 infection. Human leukocyte antigen (HLA) variation influences antiviral immune responses; however, allele-level associations with SARS-CoV-2 infection have varied across ...
Makbule Nihan Somuncu, Mahmut Selman Yıldırım, Ayşe Gül Zamani, Zahide Aleyna Yılık, Sümeyye Sultan Var   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Host receptor networking and molecular mechanisms of innate immune evasion in hepatitis E virus pathogenesis

Frontiers in Microbiology
Hepatitis E virus (HEV), the causative agent of hepatitis E, is a major global health concern, with seroprevalence estimates suggesting that approximately 939 million people worldwide have been exposed to the virus.
Ali Zohaib, Ali Zohaib, Ali Zohaib, Maham Yamin, Muhammad Usama Butt, Xing-Yi Ge, Safia S. Aljedani, Safia S. Aljedani, Safia S. Aljedani, Safia S. Aljedani, Safia S. Aljedani, Safia S. Aljedani, Rwaa Hussin Abdulal, Rwaa Hussin Abdulal, Rwaa Hussin Abdulal   +14 more
doaj   +1 more source

“Gnothi Seauton”: Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy

Vaccines, 2018
Vaccination against the seasonal influenza virus is the best way to prevent infection. Nevertheless, vaccine efficacy remains far from optimal especially in high-risk populations such as the elderly.
Hannah D. Stacey, Neda Barjesteh, Jonathan P. Mapletoft, Matthew S. Miller   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source