Results 91 to 100 of about 9,445,813 (266)

At the frontier; RXLR effectors crossing the Phytophthora -host interface [PDF]

, 2011
Plants are constantly beset by pathogenic organisms. To successfully infect their hosts, plant pathogens secrete effector proteins, many of which are translocated to the inside of the host cell where they manipulate normal physiological processes and ...
Meijer, H.J.G., Francine eGovers, Govers, F., Bouwmeester, K., Klaas eBouwmeester, Harold J. G. Meijer, Francine Govers, Harold. J.G. eMeijer, Klaas Bouwmeester   +8 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Help or Hinder: Protein Host Factors That Impact HIV-1 Replication

Viruses
Interactions between human immunodeficiency virus type 1 (HIV-1) and the host factors or restriction factors of its target cells determine the cell’s susceptibility to, and outcome of, infection.
Michael Rameen Moezpoor, Mario Stevenson
doaj   +1 more source

Host factors influencing infection and nodule development in leguminous plants

, 1952
Dr Thornton has shown that much of the diversity in the symbiosis between the leguminous plant and root-nodule bacteria can be attributed to inherent bacterial strain differences which show themselves, however, only in the symbiosis and are not causally ...
Nutman, P. S.
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

“Gnothi Seauton”: Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy

Vaccines, 2018
Vaccination against the seasonal influenza virus is the best way to prevent infection. Nevertheless, vaccine efficacy remains far from optimal especially in high-risk populations such as the elderly.
Hannah D. Stacey, Neda Barjesteh, Jonathan P. Mapletoft, Matthew S. Miller   +3 more
doaj   +1 more source

Foodborne Pathogens and Host Predilection

, 2017
During food manufacturing, the potential exists for contamination of products with pathogenic microorganisms. While the ingestion of a bacterial pathogen will typically result in illness in a susceptible host, it is not the case for each strain within a ...
David C. Bean, Laurie S. Post, Post, Laurie, Bean, David   +3 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Host sexual dimorphism and parasite adaptation [PDF]

, 2012
In species with separate sexes, parasite prevalence and disease expression is often different between males and females. This effect has mainly been attributed to sex differences in host traits, such as immune response.
Duneau, D., Ebert, Dieter, Dieter Ebert, David Duneau, Duneau David, Ebert Dieter   +5 more
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source