Results 11 to 20 of about 6,327 (248)
Towards predicting the product quality in hot-melt extrusion: Small scale extrusion
International Journal of Pharmaceutics: X, 2020 In product development, it is crucial to choose the appropriate drug manufacturing route accurately and timely and to ensure that the technique selected is suitable for achieving the desired product quality.
Josip Matić +6 more
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Inline Determination of Residence Time Distribution in Hot-Melt-Extrusion [PDF]
Pharmaceutics, 2018 In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a ...
Jens Wesholowski +2 more
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Influence of degassing on hot-melt extrusion process [PDF]
European Journal of Pharmaceutical Sciences, 2015 The present study aimed to evaluate the effect of degassing on an extrusion process, with respect to extrudate quality and drug release properties. Processed formulations were extruded with and without a degassing vent port at various locations along the barrel. All the experiments were performed under constant processing temperature, feeding rate, and
Saad M, Alshahrani +5 more
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Journal of Materials Research and Technology, 2022 Grain refinement with a facile process without additional alloying is quite desired for strengthening the Al alloys. Using the melt spinning process, we obtained the ultra-fine grained foils of Al–Mg–Si–Cu alloy (AA6061), then the foils followed by hot ...
Shuoxun Jin +5 more
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Pharmaceutics, 2020 The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid dispersion (SD ...
Sung-Min Choi +3 more
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Разработка и регистрация лекарственных средств, 2023 Introduction. Ebastine is a second-generation antihistamine drug available in the form of orally disintegrating tablets and film-coated tablets. Ebastine substance exhibits high bioavailability, but low solubility in water and gastrointestinal tract ...
K. A. Gusev +7 more
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A Review of Dynamic Models of Hot-Melt Extrusion [PDF]
Processes, 2016 Hot-melt extrusion is commonly applied for forming products, ranging from metals to plastics, rubber and clay composites. It is also increasingly used for the production of pharmaceuticals, such as granules, pellets and tablets. In this context, mathematical modeling plays an important role to determine the best process operating conditions, but also ...
Grimard, Jonathan +2 more
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FROM CONCEPT TO DELIVERY: THE EVOLUTION AND APPLICATIONS OF HOT-MELT EXTRUSION IN PHARMACEUTICALS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut UniversityHot Melt Extrusion (HME) is an innovative approach that is currently receiving significant interest in the pharmaceutical sector for the manufacturing of various dosage forms.
Jigar Vyas, Nensi Raytthatha
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Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion
Pharmaceutics, 2020 To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity in ...
Martin Spoerk +14 more
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Microstructure and refinement mechanism of Al–5Ti–1B alloys
Fenmo yejin jishu, 2022 Two kinds of Al–5Ti–1B alloys were prepared by powder mixing + hot extrusion and powder mixing + gas atomization + hot extrusion, respectively. The microstructures of the Al–5Ti–1B alloys prepared by two kinds of processes were studied, and the grain ...
LI Yang +4 more
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