Results 21 to 30 of about 6,353 (245)

Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion

Pharmaceutics, 2020
To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity in ...
Martin Spoerk, Ioannis Koutsamanis, Josip Matić, Simone Eder, Carolina Patricia Alva Zúñiga, Johannes Poms, Jesús Alberto Afonso Urich, Raymar Andreína Lara García, Klaus Nickisch, Karin Eggenreich, Andreas Berghaus, Kathrin Reusch, Yorick Relle, Johannes Khinast, Amrit Paudel   +14 more
doaj   +1 more source

Microstructure and refinement mechanism of Al–5Ti–1B alloys

Fenmo yejin jishu, 2022
Two kinds of Al–5Ti–1B alloys were prepared by powder mixing + hot extrusion and powder mixing + gas atomization + hot extrusion, respectively. The microstructures of the Al–5Ti–1B alloys prepared by two kinds of processes were studied, and the grain ...
LI Yang, GUO Xu-qiang, XU Lei, LI Chang-yun, LIU Xiao-fei   +4 more
doaj   +1 more source

Pharmaceutical Applications of Hot-Melt Extrusion: Continuous Manufacturing, Twin-Screw Granulations, and 3D Printing

Pharmaceutics, 2019
Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals [...]
Mohammed Maniruzzaman
doaj   +1 more source

Process induced degradation of carbamazepine during hot melt extrusion

British Journal of Pharmacy, 2023
The aim of this study was to evaluate hot melt extrudates of carbamazepine (CBZ) for presence of process induced degradation product iminostilbene (IMB) and quantifying using high performance liquid chromatography (HPLC). CBZ was used as model drug.
Sarbamangala Bose, Anant Paradkar, Adrian Kelly, Harika Magam   +3 more
doaj   +1 more source

Pharmaceutical Hot Melt Extrusion [PDF]

Scientia Pharmaceutica, 2010
Hot Melt Extrusion, proven state-of-the-art technology in the field of plastics, is becoming increasingly important in the pharmaceutical industry. [...]
openaire   +1 more source

Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique

Iraqi Journal of Pharmaceutical Sciences, 2018
The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone  s630 was utilized.
Ahmed S. Abdul Jabbar
doaj   +1 more source

The Development of Innovative Dosage Forms of the Fixed-Dose Combination of Active Pharmaceutical Ingredients

Pharmaceutics, 2022
The development of innovative forms of combination drugs is closely related to the invention of the multilayer tablet press, polymers for pharmaceutical applications, the hot-melt extrusion process, and 3D printing in the pharmaceutical industry. However,
Magdalena Janczura, Szymon Sip, Judyta Cielecka-Piontek   +2 more
doaj   +1 more source

Towards predicting the product quality in hot-melt extrusion: Pilot plant scale extrusion

International Journal of Pharmaceutics: X, 2021
Following our study on the impact of hot melt extrusion (HME) process conditions on the product quality, we expanded our investigation to assessing the effect of scale-up on the product quality.
Josip Matić, Carolina Alva, Simone Eder, Kathrin Reusch, Amrit Paudel, Johannes Khinast   +5 more
doaj   +1 more source

MICROSTRUCTURE AND THERMAL STABILITY OF Al-Fe-X ALLOYS

Acta Metallurgica Slovaca, 2018
In this work, Al-11Fe, Al-7Fe-4Ni and Al-7Fe-4Cr (in wt. %) alloys were prepared by combination of casting and hot extrusion. Microstructures of as-cast alloys were composed of aluminium matrix with large and coarse intermetallics such as Al13Fe4 ...
Andrea Školáková, Petra Hanusová, Filip Průša, Pavel Salvetr, Pavel Novák, Dalibor Vojtěch   +5 more
doaj   +1 more source

Rational Design of Multicomponent Polymeric Systems Based on a Transient Plasticization Window for Hot-Melt Extrusion

Pharmaceutics
Background: Hot-melt extrusion (HME) is a promising technology for the manufacturing of drug products; however, its application is limited by elevated thermal and shear stresses that may induce degradation of thermolabile active pharmaceutical ...
Mark Mandrik, Veronika Makarova, Ludmila Korol, Ivan Krasnyuk, Sergey Antonov   +4 more
doaj   +1 more source