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Pharmaceutical Hot Melt Extrusion [PDF]
Scientia Pharmaceutica, 2010 Hot Melt Extrusion, proven state-of-the-art technology in the field of plastics, is becoming increasingly important in the pharmaceutical industry. [...]
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Pharmaceutics, 2019 Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals [...]
Mohammed Maniruzzaman
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Process induced degradation of carbamazepine during hot melt extrusion
British Journal of Pharmacy, 2023 The aim of this study was to evaluate hot melt extrudates of carbamazepine (CBZ) for presence of process induced degradation product iminostilbene (IMB) and quantifying using high performance liquid chromatography (HPLC). CBZ was used as model drug.
Sarbamangala Bose +3 more
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Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique
Iraqi Journal of Pharmaceutical Sciences, 2018 The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone s630 was utilized.
Ahmed S. Abdul Jabbar
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Pharmaceutics, 2022 The development of innovative forms of combination drugs is closely related to the invention of the multilayer tablet press, polymers for pharmaceutical applications, the hot-melt extrusion process, and 3D printing in the pharmaceutical industry. However,
Magdalena Janczura +2 more
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MICROSTRUCTURE AND THERMAL STABILITY OF Al-Fe-X ALLOYS
Acta Metallurgica Slovaca, 2018 In this work, Al-11Fe, Al-7Fe-4Ni and Al-7Fe-4Cr (in wt. %) alloys were prepared by combination of casting and hot extrusion. Microstructures of as-cast alloys were composed of aluminium matrix with large and coarse intermetallics such as Al13Fe4 ...
Andrea Školáková +5 more
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Towards predicting the product quality in hot-melt extrusion: Pilot plant scale extrusion
International Journal of Pharmaceutics: X, 2021 Following our study on the impact of hot melt extrusion (HME) process conditions on the product quality, we expanded our investigation to assessing the effect of scale-up on the product quality.
Josip Matić +5 more
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Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation
Pharmaceutics, 2018 A validation for the use of model-based melt viscosity in hot-melt extrusion numerical simulations was presented. Here, the melt viscosity of an amorphous solid dispersion (ASD) was calculated by using its glass transition temperature (Tg) and the ...
Esther S. Bochmann +2 more
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PharmaceuticsBackground: Hot-melt extrusion (HME) is a promising technology for the manufacturing of drug products; however, its application is limited by elevated thermal and shear stresses that may induce degradation of thermolabile active pharmaceutical ...
Mark Mandrik +4 more
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In-process rheometry as a PAT tool for hot melt extrusion [PDF]
Drug Development and Industrial Pharmacy, 2017 Real time measurement of melt rheology has been investigated as a Process Analytical Technology (PAT) to monitor hot melt extrusion of an Active Pharmaceutical Ingredient (API) in a polymer matrix. A developmental API was melt mixed with a commercial copolymer using a heated twin screw extruder at different API loadings and set temperatures.
Kelly, Adrian L. +7 more
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