Development and Characterization of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology [PDF]
Pharmaceutics, 2021 The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers.
Abdullah Alshetaili +3 more
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Accelerated Oral Healing by Angelica gigas Nakai from Hot Melt Extrusion Technology: An In Vitro Study [PDF]
Medicina, 2023 Background and Objectives: In spite of the oral environment being healing-prone, its dynamic changes may affect wound healing. The purpose of this study was to assess the oral wound healing effect of Angelica gigas Nakai (AG) prepared by hot-melt ...
Ju Ri Ye +6 more
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Formulation development of itraconazole PEGylated nano-lipid carriers for pulmonary aspergillosis using hot-melt extrusion technology [PDF]
International Journal of Pharmaceutics: X, 2021 Pulmonary delivery is a promising alternative for the oral treatment of pulmonary aspergillosis. This study aimed to develop continuous and scalable itraconazole PEGylated nano-lipid carriers (ITZ-PEG-NLC) for inhalation delivery.
Gauri Shadambikar +7 more
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Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products
Pharmaceutics, 2020 Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug.
Ana Luiza Lima +7 more
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Enhanced Dissolution and Bioavailability of Curcumin Nanocrystals Prepared by Hot Melt Extrusion Technology [PDF]
International Journal of NanomedicineYujie Zhao,1 Xiaoyin Xu,1 Anyin Dai,2 Yunxiang Jia,1 Wenxi Wang1 1College of Pharmacy, Zhejiang University of Technology, Hangzhou, People’s Republic of China; 2Department of Pharmacy, The 903rd Hospital of People’s Liberation Army, Hangzhou, People’s ...
Zhao Y, Xu X, Dai A, Jia Y, Wang W
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Process Development for the Continuous Manufacturing of Carbamazepine-Nicotinamide Co-Crystals Utilizing Hot-Melt Extrusion Technology [PDF]
PharmaceuticsObjectives: Hot-melt extrusion (HME) offers a solvent-free, scalable approach for manufacturing pharmaceutical co-crystals (CCs), aligning with the industry’s shift to continuous manufacturing (CM).
Lianghao Huang +6 more
doaj +2 more sources
Development and in vitro Evaluation of Cannabidiol Mucoadhesive Buccal Film Formulations Using Hot-Melt Extrusion Technology [PDF]
Medical Cannabis and CannabinoidsIntroduction: Cannabidiol (CBD) has sparked considerable interest because of its wide range of pharmacological uses and the fact that it does not induce psychoactive effects.
Iman E. Taha +5 more
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Exploring the pivotal role of hot melt extrusion technology in developing PLGA based novel drug delivery platforms for better therapeutic outcomes [PDF]
Saudi Pharmaceutical JournalAmong various biodegradable polymers, polylactic-co-glycolic acid (PLGA) is one of most widely studied synthetic polymer for controlled and targeted drug delivery. PLGA is a smart polymer as it has stimuli-responsive behaviour. PLGA is approved by the US
Mashan Almutairi +7 more
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Precision Drug Delivery of LY-11h for Acute Myeloid Leukemia Treatment Using Machine Learning-Assisted Hot Melt Extrusion and 3D-Printed Technologies [PDF]
PharmaceuticsBackground: Acute myeloid leukemia (AML) is a heterogeneous and aggressive hematologic malignancy, and LY-11h is a novel acylhydrazide-based histone deacetylase inhibitor with promising therapeutic potential for AML. However, its poor aqueous solubility,
Lianghao Huang +6 more
doaj +2 more sources
Pharmaceutics, 2018 This paper displays the potential of an in-line PAT system for early phase product development during pharmaceutical continuous manufacturing following a Quality by Design (QbD) framework.
Walkiria Schlindwein +5 more
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