Results 21 to 30 of about 8,963,828 (215)

Coupling Additive Manufacturing with Hot Melt Extrusion Technologies to Validate a Ventilator-Associated Pneumonia Mouse Model

Pharmaceutics, 2021
Additive manufacturing is widely used to produce highly complex structures. Moreover, this technology has proven its superiority in producing tools which can be used in different applications.
Bahaa Shaqour, Juliana Aizawa, Clara Guarch-Pérez, Żaneta Górecka, Lars Christophersen, Wim Martinet, Emilia Choińska, Martijn Riool, Bart Verleije, Koen Beyers, Claus Moser, Wojciech Święszkowski, Sebastian A. J. Zaat, Paul Cos   +13 more
doaj   +1 more source

Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions

Pharmaceutics, 2022
Amorphous solid dispersions (ASD) are one of the most prominent formulation approaches to overcome bioavailability issues that are often presented by new poorly soluble drug candidates. State-of-the art manufacturing techniques include hot melt extrusion
Malin Hermeling, Christoph Nueboldt, Roman Heumann, Werner Hoheisel, Joerg Breitkreutz   +4 more
doaj   +1 more source

Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology [PDF]

Expert Opinion on Drug Delivery, 2015
Jun-Bom Park, Shabana Khan, Michael Repka   +2 more
exaly   +2 more sources

Preparation of Hot-Melt Extruded Dosage Form for Enhancing Drugs Absorption Based on Computational Simulation

Pharmaceutics, 2020
The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid dispersion (SD ...
Sung-Min Choi, Sung-Hoon Lee, Chin-Yang Kang, Jun-Bom Park   +3 more
doaj   +1 more source

Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet Substrates

Pharmaceutics, 2023
Since 3D printing allows for patient-specific dosage forms, it has become a major focus in pharmaceutical research. However, it is difficult to scale up drug product manufacturing. Injection molding has been used in conjunction with hot-melt extrusion to
Han Xu, Farnoosh Ebrahimi, Ke Gong, Zhi Cao, Evert Fuenmayor, Ian Major   +5 more
doaj   +1 more source

Preparation of Solid Dispersion of Polygonum Cuspidatum Extract by Hot Melt Extrusion to Enhance Oral Bioavailability of Resveratrol

Molecules, 2023
The aim of this study was to improve the solubility, bioavailability, and stability of resveratrol (RES-SD) Solid Dispersion in Polygonum cuspidatum extract (PCE) by hot melt extrusion (HME).
Wenling Fan, Jiali Wu, Meiqi Gao, Xiaotong Zhang, Wenjing Zhu   +4 more
doaj   +1 more source

Study of the Technological Methods Effect on Dissolution of the X-ray Amorphous Efavirenz-mesoporous Carrier System

Разработка и регистрация лекарственных средств, 2022
Introduction. The low solubility of active pharmaceutical ingredients (APIs) in the physiological pH range of the intestinal tract can adversely affect their absorption and bioavailability.
S. A. Zolotov, N. B. Demina, E. S. Ponomarev, I. A. Dain, A. S. Zolotova   +4 more
doaj   +1 more source

FROM CONCEPT TO DELIVERY: THE EVOLUTION AND APPLICATIONS OF HOT-MELT EXTRUSION IN PHARMACEUTICALS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Hot Melt Extrusion (HME) is an innovative approach that is currently receiving significant interest in the pharmaceutical sector for the manufacturing of various dosage forms.
Jigar Vyas, Nensi Raytthatha
doaj   +1 more source

Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing

Pharmaceutics, 2020
This study was performed to develop novel core-shell gastroretentive floating pulsatile drug delivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM) 3D printing and direct compression method.
Nagi Reddy Dumpa, Suresh Bandari, Michael A. Repka   +2 more
doaj   +1 more source

Application of Lipids in Hot Melt Extrusion Technology [PDF]

, 2023
Lipids are commonly used excipients in drug delivery for improving solubility of low soluble drugs, enhancing bioavailability through avoiding first pass metabolism through nanoparticulate approach, modifying the drug release, binders, permeation ...
Dindigala, Anil Kumar, Mounika Rajya Lakshmi Kodam, Kodam, Mounika Rajya Lakshmi, Anil Kumar Dindigala   +3 more
core   +1 more source