Results 31 to 40 of about 2,837,475 (309)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Collaborative Performance Research on Multi-level Hospital Management Based on Synergy Entropy-HoQ

Entropy, 2015
Because of the general lack of multi-level hospital management collaboration performance effectiveness research, this paper proposes a multi-level hospital management Synergy Entropy-House of Quality (HoQ) Measurement Model by innovatively combining the ...
Lei Chen, Xuedong Liang, Tao Li
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Service user and carer involvement in mental health care safety: raising concerns and improving the safety of services

BMC Health Services Research, 2018
Background Previous research into improving patient safety has emphasised the importance of responding to and learning from concerns raised by service users and carers.
Kathryn Berzins, Gemma Louch, Mark Brown, Jane K. O’Hara, John Baker   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

QFD-based conceptual design of an autonomous underwater robot [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2015
Autonomous underwater robots in the past few years have been designed according to the individual concepts and experiences of the researchers. To design a robot, which meets all the requirements of potential users, is an advanced work.
Thip Pasawang, Theerayuth Chatchanayuenyong, Worawat Sa-Ngiamvibool   +2 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

ENHANCING SERVICE EFFICIENCY IN UTILITY ORGANIZATIONS THROUGH QUALITY FUNCTION DEPLOYMENT

International Journal of Management Studies
Quality Function Deployment (QFD) is a powerful approach for establishing a strong relationship between a product or service and customer needs. It focuses on capturing the voice of the customer to enhance their satisfaction.
Maryam Shahid, Rafiq Mansoor, Muhammad Shahid, Syed Athar Masood   +3 more
doaj   +1 more source

INTEGRASI SERVQUAL DAN QUALITY FUNCTION DEPLOYMENT UNTUK PENGUKURAN KUALITAS LAYANAN (STUDI KASUS: PROGRAM STUDI PENDIDIKAN TEKNIK MESIN, UNIVERSITAS PALANGKA RAYA)

Journal of Engineering and Management in Industrial System, 2013
Services in Program Studi Pendidikan Teknik Mesin (PSPTM) still has drawbacks, among other complaints for cleanliness wc, and class. This indicates or identifies a student dissatisfaction against poor service.
Wiyogo Wiyogo, Surachman Surachman, Rudy Soenoko, Nasir Widha Setyanto   +3 more
doaj   +1 more source