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Fast sequence evolution of
BMC Evolutionary Biology, 2006 Background It is expected that genes that are expressed early in development and have a complex expression pattern are under strong purifying selection and thus evolve slowly. Hox genes fulfill these criteria and thus, should have a low evolutionary rate.
Barbadilla Antonio +3 more
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Collinear Hox-Hox interactions are involved in patterning the vertebrate anteroposterior (A-P) axis. [PDF]
PLoS ONE, 2017 Investigating regulation and function of the Hox genes, key regulators of positional identity in the embryo, opened a new vista in developmental biology.
Kongju Zhu +2 more
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The murine genes Hox-5.1 and Hox-4.1 belong to the same HOX complex on chromosome 2
Genomics, 1990 Two different loci of Antennapedia-related homeobox-containing genes have been shown to map to mouse chromosome 2: the HOX-5 complex and the Hox-4.1 gene.
Lehrach, H. +5 more
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Journal of Ovarian Research, 2011 The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development. Here we review a number of recent studies showing that HOX genes are strongly expressed in ovarian cancer, and that in some ...
Kelly Zoë L +4 more
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, 2009 Hox geni se neprestano javljaju kao ključni čimbenici u embrionalnom razvitku i evoluciji. Zajedno s drugim genima čine signalne mreže, djelujući kao modulatori ili pak sudjeluju u formiranju novih struktura.
Bergman, Juraj
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Using the conserved hexapeptide in HOX proteins as an antagonist of HOX/PBX interactions [PDF]
The HOX and PBX genes encode transcription factors that have key roles in development and cancer, both independently and as a heterodimer within a complex of proteins that recognizes specific sequences in DNA and can both activate or repress ...
Morgan, Richard +2 more
core +2 more sources
Evolution of Cyclostome Hox Clusters [PDF]
, 2023 Hagfish and lampreys represent the only two lineages of agnathan (jawless) vertebrates that have survived to the present day, and both form the monophyletic group of cyclostomes, which is sister to the rest of the vertebrates, the gnathostomes (jawed ...
Christine Böhmer +3 more
core +1 more source
HOX Pro DB: the functional genomics of hox ensembles [PDF]
Nucleic Acids Research, 2002 The HOX Pro database contains information about the organization, function and evolution of gene ensembles, notably the homeobox-containing genes. It is now clear that a subset of genes containing the homeobox motif play key roles in the orchestration of genes which control embryonic patterning, morphogenesis, cell differentiation and malignant ...
Alexander V. Spirov +2 more
openaire +2 more sources
Hox-1.11 and Hox-4.9 homeobox genes. [PDF]
Proceedings of the National Academy of Sciences, 1992 Mouse Hox-1.11 and Hox-4.9 genes were cloned, and the nucleotide sequences of the homeobox regions were determined. In addition, nucleotide sequence analysis of the homeobox regions of cloned Hox-4.3 and Hox-4.2 genomic DNA revealed some differences in nucleotide sequences and in the deduced homeodomain amino acid sequences compared with the sequences ...
A, Nazarali, Y, Kim, M, Nirenberg
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The Hox-TALE has been wagging for a long time [PDF]
, 2014 Hox and TALE proteins interact in a sea anemone, just as they do in flies and mice, indicating that the Hox-TALE system originated very early in animal evolution.Peer ...
David EK Ferrier +2 more
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