The TALE face of Hox proteins in animal evolution
Frontiers in Genetics, 2015 Hox genes are major regulators of embryonic development. One of their most conserved functions is to coordinate the formation of specific body structures along the anterior-posterior (AP) axis in Bilateria.
Samir eMerabet, Brigitte eGalliot
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Function of synthetic Hox transcription factors "in vivo" and the quantitative study of their molecular interactions with nuclear DNA at the single-molecule level in live cells [PDF]
, 2010 Over a century of research, invested in providing an answer to the fundamental question of how a single diploid cell constructs a whole organism, has placed Drosophila in the fore scene of developmental biology and has allowed us to merge the knowledge ...
Papadopoulos, Dimitrios
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Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors. [PDF]
PLoS Biology, 2012 Hox transcription factors control a number of developmental processes with the help of the PBC class proteins. In vitro analyses have established that the formation of Hox/PBC complexes relies on a short conserved Hox protein motif called the hexapeptide
Bruno Hudry +5 more
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American Journal of Respiratory Cell and Molecular Biology, 1996 Hox genes are a specific subgroup of homeobox containing genes that are characterized by their structural and functional homology to homeotic genes of the fruit fly Drosophila (1). These genes play important roles in pattern formation along the anterior-posterior axis in the developing embryo in both invertebrates and vertebrates (2).
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Chromatin accessibility plays a key role in selective targeting of Hox proteins
Genome Biology, 2019 Background Hox transcription factors specify segmental diversity along the anterior-posterior body axis in metazoans. While the different Hox family members show clear functional specificity in vivo, they all show similar binding specificity in vitro and
Damiano Porcelli +3 more
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Molecular Oncology, 2021 In human, the 39 coding HOX genes and 18 referenced noncoding antisense transcripts are arranged in four genomic clusters named HOXA, B, C, and D. This highly conserved family belongs to the homeobox class of genes that encode transcription factors ...
Elisa Le Boiteux +10 more
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Do Sojourn Effects on Personality Trait Changes Last? A Five‐Year Longitudinal Study
European Journal of Personality, EarlyView., 2020 Abstract This study examined sojourners' long‐term personality trait changes over five years, extending previous research on immediate sojourn effects. A sample of German students (N = 1095) was surveyed thrice (T1–T3) over the course of an academic year.
Julia Richter +4 more
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Composition and genomic organization of arthropod Hox clusters
EvoDevo, 2016 Background The ancestral arthropod is believed to have had a clustered arrangement of ten Hox genes. Within arthropods, Hox gene mutations result in transformation of segment identities.
Ryan M. Pace +2 more
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Distinct molecular strategies for Hox-mediated limb suppression in Drosophila: from cooperativity to dispensability/antagonism in TALE partnership. [PDF]
PLoS Genetics, 2013 The emergence following gene duplication of a large repertoire of Hox paralogue proteins underlies the importance taken by Hox proteins in controlling animal body plans in development and evolution. Sequence divergence of paralogous proteins accounts for
Nagraj Sambrani +6 more
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The origin of the Hox and ParaHox loci and animal homeobox evolution [PDF]
, 2015 The homeobox superfamily is one of the most significant gene families in the evolution of developmental processes in animals. Within this superfamily the ANTP class has expanded exclusively in animals and, therefore, the reconstruction of its origin ...
Mendivil Ramos, Olivia
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