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Hox genes in development and beyond
Development, 2023ABSTRACT Hox genes encode evolutionarily conserved transcription factors that are essential for the proper development of bilaterian organisms. Hox genes are unique because they are spatially and temporally regulated during development in a manner that is dictated by their tightly linked genomic organization.
Katharine A. Hubert, Deneen M. Wellik
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2014
How transcription is controlled by distally located cis regulatory elements is an active area of research in biology. As such there have been many techniques developed to probe these long distance chromatin interactions. Here we focus on one such method called DamID (van Steensel and Henikoff Nat Biotechnol 18(4):424 428 2000). While other methods like
Cléard Fabienne +2 more
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How transcription is controlled by distally located cis regulatory elements is an active area of research in biology. As such there have been many techniques developed to probe these long distance chromatin interactions. Here we focus on one such method called DamID (van Steensel and Henikoff Nat Biotechnol 18(4):424 428 2000). While other methods like
Cléard Fabienne +2 more
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Hox genes in a pentameral animal
BioEssays, 2001There is renewed interest in how the different body plans of extant phyla are related. This question has traditionally been addressed by comparisons between vertebrates and Drosophila. Fortunately, there is now increasing emphasis on animals representing other phyla.
E, Popodi, R A, Raff
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The FASEB Journal, 1996
The vertebrate embryonic body plan is constructed through the interaction of many de‐ velopmentally regulated genes that supply cells with the essential positional and functional information they require to migrate to their appropriate destination and generate the proper structures.
H, Marshall +4 more
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The vertebrate embryonic body plan is constructed through the interaction of many de‐ velopmentally regulated genes that supply cells with the essential positional and functional information they require to migrate to their appropriate destination and generate the proper structures.
H, Marshall +4 more
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Hox genes and animal regeneration
Russian Journal of Developmental Biology, 2016The concept of regeneration is intimately associated with ideas about positional information, that is, the distribution of various signals prescribing cells their location in an embryo or an adult organism. Hox genes are perfect candidates for the role of factors creating positional information.
E L, Novikova +3 more
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Hox genes and the making of sphincters
Nature, 1999Hoxd genes are needed for the formation of sphincters to subdivide the developing gut. As well as their shared role in the anteroposterior patterning of vertebrates1, particular Hox gene com-plexes have evolved specific functions. For example, four consecutive genes of the HoxD cluster contribute to making proper digits2,3.
Zakany, J., Duboule, D.
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Hox genes and kidney development
Pediatric Nephrology, 2011The adult mammalian kidney is generated by the differentiation and integration of several distinct cell types, including the nephrogenic mesenchyme, ureteric epithelium, stromal and endothelial cells. How and where these cell types are generated and what signals lead to their differentiation and integration into a functional organ system is a main ...
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Genomics of the HOX gene cluster
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2002The Hox family of homeobox genes encode transcription factors that control different aspects of metazoan development. They appear clustered in the genomes of those animals in which their relative positions have been mapped. Although clustering is assumed to be a general property of Hox genes in all bilaterians, just a few species have been studied in ...
Pedro, Martinez, Chris T, Amemiya
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Seminars in Reproductive Medicine, 2007
Implantation is a complex event requiring synchronization between a developing embryo and receptive endometrium. This process is governed by molecular mechanism mediated by homeobox (Hox) genes, which encode transcription factors. These factors guide embryologic development as well as regulate differential gene expression within the endometrium with ...
Danielle, Vitiello +2 more
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Implantation is a complex event requiring synchronization between a developing embryo and receptive endometrium. This process is governed by molecular mechanism mediated by homeobox (Hox) genes, which encode transcription factors. These factors guide embryologic development as well as regulate differential gene expression within the endometrium with ...
Danielle, Vitiello +2 more
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Annual Review of Genetics, 1994
control of metazoan organisms. In this article, we review the distribution of this gene family in selected species of the major phyla of metazoans, and from these data evaluate the usefulness of this system for establishing phyletic affinities, and the potential of using developmental genes as a means of ob taining insights into evolutionary mecha ...
F H, Ruddle +5 more
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control of metazoan organisms. In this article, we review the distribution of this gene family in selected species of the major phyla of metazoans, and from these data evaluate the usefulness of this system for establishing phyletic affinities, and the potential of using developmental genes as a means of ob taining insights into evolutionary mecha ...
F H, Ruddle +5 more
openaire +2 more sources