Results 41 to 50 of about 2,727,731 (214)

Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression. [PDF]

PLoS ONE, 2011
Hox genes play important roles in haematopoietic development in mammals. ASH1 is a member of the trithorax group (trxG) that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem cells.
Yujiro Tanaka, Koji Kawahashi, Zen-Ichiro Katagiri, Yasuhiro Nakayama, Milind Mahajan, Dimitris Kioussis   +5 more
doaj   +1 more source

The rapid variation of Hox clusters reveals a clear evolutionary path in a crucian carp-like homodiploid fish lineage

Reproduction and Breeding, 2021
The surprising variation in the number of Hox clusters and genome structure in ray-finned fish lineages reflects the history of duplications and subsequent lineage-specific gene loss.
Shi Wang, Qilong Liu, Xuexue Huang, Conghui Yang, Lan Chen, Mei Han, Yuqin Shu, Min Wang, Wuhui Li, Fangzhou Hu, Ming Wen, Kaikun Luo, Yude Wang, Rong Zhou, Chun Zhang, Min Tao, Rurong Zhao, Chenchen Tang, Shaojun Liu   +18 more
doaj   +1 more source

HOX Gene Expressions in Cultured Articular and Nasal Equine Chondrocytes [PDF]

, 2023
Osteoarthritis the quality and span of life in horses. Previous studies focused on nasal cartilage as a possible source for autologous chondrocyte implantation (ACI) in cartilage defects in humans. “HOX gene-negative” nasal chondrocytes adapted articular
Fuhrmann, Herbert, Storch, Christiane, Schoeniger, Axel   +2 more
core   +3 more sources

Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes. [PDF]

PLoS ONE, 2007
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98.
Lars Palmqvist, Nicolas Pineault, Carina Wasslavik, R Keith Humphries   +3 more
doaj   +1 more source

Methylation in HOX Clusters and Its Applications in Cancer Therapy

Cells, 2020
HOX genes are commonly known for their role in embryonic development, defining the positional identity of most structures along the anterior–posterior axis.
Ana Paço, Simone Aparecida de Bessa Garcia, Renata Freitas   +2 more
doaj   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Hox genes reveal genomic DNA variation in tetraploid hybrids derived from Carassius auratus red var. (female) × Megalobrama amblycephala (male)

BMC Genetics, 2017
Background Allotetraploid F1 hybrids (4nF1) (AABB, 4n = 148) were generated from the distant hybridization of Carassius auratus red var. (RCC) (AA, 2n = 100) (♀) × Megalobrama amblycephala (BSB) (BB, 2n = 48) (♂).
Y. D. Wang, Q. B. Qin, R. Yang, W. Z. Sun, Q. W. Liu, Y. Y. Huo, X. Huang, M. Tao, C. Zhang, T. Li, S. J. Liu   +10 more
doaj   +1 more source

Hox genes in hematopoiesis and leukemogenesis [PDF]

Oncogene, 2007
Gene expression analyses, gene targeting experiments and retroviral overexpression studies in the murine bone marrow transplantation model have provided strong correlative evidence for the involvement of clustered Hox genes in normal hematopoiesis. The data strongly support the hypothesis that the role of Hox genes in normal hematopoiesis is primarily ...
B, Argiropoulos, R K, Humphries
openaire   +2 more sources

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation

Epigenetics, 2018
Homeobox (HOX) genes are frequently dysregulated in leukemia. Previous studies have shown that aberrant HOX gene expression accompanies leukemogenesis and affects disease progression and leukemia patient survival.
Katerina Rejlova, Alena Musilova, Karolina Skvarova Kramarzova, Marketa Zaliova, Karel Fiser, Meritxell Alberich-Jorda, Jan Trka, Julia Starkova   +7 more
doaj   +1 more source