Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]
, 2011 The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Glenda J. Dickson +16 more
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American Journal of Respiratory Cell and Molecular Biology, 1996 Hox genes are a specific subgroup of homeobox containing genes that are characterized by their structural and functional homology to homeotic genes of the fruit fly Drosophila (1). These genes play important roles in pattern formation along the anterior-posterior axis in the developing embryo in both invertebrates and vertebrates (2).
openaire +2 more sources
Neuroblast lineage identification and Hox gene action during postembryonic development of the tritocerebrum and subesophageal ganglion in the "Drosophila" brain [PDF]
, 2013 In this thesis, the neuroblast lineages which give rise to the adult-specific interneurons of two Drosophila brain regions, the tritocerebrum and the subesophageal ganglion, were described, and an analysis of the expression and function of the ...
Kuert, Philipp A.
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Composition and genomic organization of arthropod Hox clusters
EvoDevo, 2016 Background The ancestral arthropod is believed to have had a clustered arrangement of ten Hox genes. Within arthropods, Hox gene mutations result in transformation of segment identities.
Ryan M. Pace +2 more
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Modeling a Hox Gene Network: Stochastic Simulation with Experimental Perturbation [PDF]
, 2003 The Hox genes show a striking segment specific pattern of expression in a variety of vertebrate embryos, and have been the topic of many experimental analyses.
Kastner, Jason Christopher
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The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain [PDF]
, 2012 The developing brain of Drosophila has become a useful model for studying the molecular genetic mechanisms that give rise to the complex neuronal arrays that characterize higher brains in other animals including mammals.
Reichert, H. +8 more
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Multifactorial regulation of a hox target gene. [PDF]
PLoS Genetics, 2009 Hox proteins play fundamental roles in controlling morphogenetic diversity along the anterior-posterior body axis of animals by regulating distinct sets of target genes.
Petra Stöbe +7 more
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The origin of the Hox and ParaHox loci and animal homeobox evolution [PDF]
, 2015 The homeobox superfamily is one of the most significant gene families in the evolution of developmental processes in animals. Within this superfamily the ANTP class has expanded exclusively in animals and, therefore, the reconstruction of its origin ...
Mendivil Ramos, Olivia
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Features of the ancestral bilaterian inferred from Platynereis dumerilii ParaHox genes [PDF]
, 2009 Background The ParaHox gene cluster is the evolutionary sister to the Hox cluster. Whilst the role of the Hox cluster in patterning the anterior-posterior axis of bilaterian animals is well established, and the organisation of vertebrate Hox clusters is ...
Segurens Béatrice +47 more
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Contributions of HOX genes to cancer hallmarks: Enrichment pathway analysis and review
Tumor Biology, 2020 Homeobox genes function as master regulatory transcription factors during development, and their expression is often altered in cancer. The HOX gene family was initially studied intensively to understand how the expression of each gene was involved in ...
Danielle Barbosa Brotto +11 more
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