Results 31 to 40 of about 27,788 (178)
Hox gene expression in postmetamorphic juveniles of the brachiopod Terebratalia transversa
EvoDevo, 2019 Background Hox genes encode a family of homeodomain containing transcription factors that are clustered together on chromosomes of many Bilateria.
Ludwik Gąsiorowski, Andreas Hejnol
doaj +1 more source
BMC Biology, 2009 Background Hox genes are critical for patterning the bilaterian anterior-posterior axis. The evolution of their clustered genomic arrangement and ancestral function has been debated since their discovery. As acoels appear to represent the sister group to
Hejnol Andreas, Martindale Mark Q
doaj +1 more source
Seeking Sense in the Hox Gene Cluster
Journal of Developmental Biology, 2022 The Hox gene cluster, responsible for patterning of the head–tail axis, is an ancestral feature of all bilaterally symmetrical animals (the Bilateria) that remains intact in a wide range of species.
Stephen J. Gaunt
doaj +1 more source
Scientific Reports, 2021 Hox genes are key developmental regulators that are involved in establishing morphological features during animal ontogeny. They are commonly expressed along the anterior–posterior axis in a staggered, or collinear, fashion.
David A. Salamanca-Díaz +3 more
doaj +1 more source
Advanced Science, EarlyView.HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun +12 more
wiley +1 more source
Genome-Wide Binding of Posterior HOXA/D Transcription Factors Reveals Subgrouping and Association with CTCF. [PDF]
PLoS Genetics, 2017 Homeotic genes code for key transcription factors (HOX-TFs) that pattern the animal body plan. During embryonic development, Hox genes are expressed in overlapping patterns and function in a partially redundant manner.
Ivana Jerković +9 more
doaj +1 more source
Hox genes in hematopoiesis and leukemogenesis [PDF]
Oncogene, 2007 Gene expression analyses, gene targeting experiments and retroviral overexpression studies in the murine bone marrow transplantation model have provided strong correlative evidence for the involvement of clustered Hox genes in normal hematopoiesis. The data strongly support the hypothesis that the role of Hox genes in normal hematopoiesis is primarily ...
B, Argiropoulos, R K, Humphries
openaire +2 more sources
Advanced Science, EarlyView.Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang +11 more
wiley +1 more source
Identification, Evolution and Expression Analyses of the Hox Family in Procambarus clarkii
Progress in Fishery SciencesHomeobox genes are ubiquitous in eukaryotic genomes and can be transcribed into a homeodomain of approximately 60 amino acids. Hox genes are currently the most studied class of homeobox genes.
Xiaoyu WEI, Qian HU, Zemao GU, Yanhe LI
doaj +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac +16 more
wiley +1 more source