Results 41 to 50 of about 174,417 (293)

A Non-Invasive Strategy for Neonatal Alloimmune Thrombocytopenia Diagnosis: Newborn Platelet Genotyping with Buccal Swabs

International Journal of Neonatal Screening, 2016
Neonatal alloimmune thrombocytopenia results from the maternal immune response against fetal-specific antigens inherited from the father. The diagnosis is ascertained only when the maternal alloantibody and the offending antigen present in the newborn ...
Gérald Bertrand, Cécile Kaplan
doaj   +1 more source

A Practical and Efficient Multiplex qPCR Assay for Simultaneous Detection of HLA Cross-Reactive Groups and Human Platelet Antigens. [PDF]

J Clin Lab Anal
This assay enables multiplex genotyping of HLA‐CREGs and HPA alleles from whole blood using qPCR with an integrated parallel negative control. Results are interpreted based on amplification curves and Ct values, with validity dependent on strict quality control criteria for both the target reactions and the negative control.
Ji H, Feng K, Xu Y, Chang L, Yan Y, Ma J, Liu Y, Zeng J, Sun H, Wang L.   +9 more
europepmc   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Predictive power of Koplik’s spots for the diagnosis of measles

Journal of Infection in Developing Countries, 2011
Introduction: Measles is a major cause of mortality globally. In many countries, management of measles is based on clinical suspicion, but the predictive value of clinical diagnosis depends on knowledge and population prevalence of measles.
Dominik Zenner, Luis Nacul
doaj   +1 more source

The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression. [PDF]

, 2009
In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated. In 114 depressed inpatients suffering from unipolar or bipolar depression (sample 1) the DEX/CRH test was ...
Daniela Eser, Baghai Thomas C., Herrmann, Sascha, Rupprecht Rainer, Born, Christoph, Sascha Herrmann, Schüle Cornelius, Cornelius Schüle, Sibylle Häfner, Rupprecht, Rainer, Häfner Sibylle, Eser, Daniela, Schüle, Cornelius, Baghai, Thomas C., Herrmann Sascha, Christoph Born, Rainer Rupprecht, Thomas C. Baghai, Häfner, Sibylle, Thomas C Baghai, Eser Daniela, Born Christoph   +21 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Frequency of human platelet antigens in oncohematological patients with thrombocytopenia and the probability of incompatibility to platelet transfusions Frequência dos antígenos plaquetários humanos (HPA) em pacientes trombocitopênicos e predisposição à incompatibilidade transfusional

Revista Brasileira de Hematologia e Hemoterapia, 2012
OBJECTIVE: The objective of this study was to evaluate the frequencies of human platelet antigens in oncohematological patients with thrombocytopenia and to analyze the probability of their incompatibility with platelet transfusions.
Juliana Vieira dos Santos Bianchi, Maria Regina Andrade de Azevedo, Eduardo Jens, Youko Nukui, Dalton Alencar Ficher Chamone   +4 more
doaj   +1 more source

Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia [PDF]

Терапевтический архив, 2018
The aim. Mechanisms underlying the development of neonatal alloimmune thrombocytopenia (NAIT) in in Russia have been studied. Materials and methods. Genetic polymorphisms of human platelet alloantigens (HPA) -1, -2, -3, -4, -5, and -15 were evaluated in ...
S G KHASPEKOVA, L L GOLOVKINA, E K DONUSH, N V GOLUBEVA, O N SHUSTOVA, A V MAZUROV   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source