Results 81 to 90 of about 174,417 (293)
Advanced Science, EarlyView.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
wiley +1 more source
Frequency of H.Pylory BabA2 and Hpa Genes in Patients with Dysphagia
Medical Laboratory Journal, 2015 Background and Objective: BabA2 and Hpa genes are involved in adherence of Helicobacter pylori (H.pylori) to gastric mucosal tissue. This study aimed to investigate the frequency of these genes in isolates of H.
Khatoon Heydari +4 more
doaj
Zhongguo shiyan zhenduanxue, 2021 目的研究岳阳汉族人群人类血小板抗原基因多态性。方法采用PCR-SSP方法对374名血小板固定捐献志愿者进行血小板抗原HPA-1-6,15,21系统基因分型,直接计算基因频率,采用统计学方法研究基因多态性。结果HPA-3、HPA-15系统基因表现型ab频率高于aa,HPA-1、HPA-2、HPA-4、HPA-5、HPA-6、HPA-21系统基因表现型以aa为主,HPA-15、HPA-3抗原不配合率最高。结论岳阳汉族人群HPA分布具有多态性,HPA-2、HPA-3、HPA-5、HPA ...
苏湘晖 +4 more
doaj
Characteristics of QBWO over the East Asian Monsoon Region Presented by Different Elements
应用气象学报, 2020 Different variables present discrepancy in characteristics of the quasi-biweekly oscillation (QBWO), which is a dominant sub-seasonal signal in the East Asian monsoon regime.
Li Jingyi, Wang Zunya, Wen Min
doaj +1 more source
Advanced Science, EarlyView.Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen +11 more
wiley +1 more source
Angewandte Chemie, EarlyView.Supramolecular 1‐D, 2‐D, and 3‐D networks comprised of ‐(‐O═Xe(O2)‐‐)‐∞ and ‐(‐Xe(O2)O‐‐‐HO(H)‐‐)‐∞ chains coordinated to polytopic N‐base ligands were synthesized and structurally characterized by X‐ray crystallography. Their Xe‐‐‐N and Xe‐‐‐O bonds are characteristic of σ–hole bonds in which the nucleophilic Lewis base sites of the N‐ligands, H2O ...
James T. Goettel +2 more
wiley +2 more sources
Advanced Science, EarlyView.Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao +9 more
wiley +1 more source
Intercomparison in barometric pressure:Range 510 hPa to 1100 hPa
, 2009 Mittatekniikan keskus (MIKES) järjesti 2008-2009 paineen vertailumittauksen barometrialueella 510 hPa...1100 hPa. Vertailumittaukseen osallistui neljä akkreditoitua paineen kalibrointilaboratoriota Suomesta.
Rantanen, Markku, Saxholm, Sari
core +4 more sources
HPA-axis functioning and the onset of psychosis in an 'ultra' high-risk group
, 2004 HPA-axis functioning and the onset of psychosis in an 'ultra' high-risk ...
S Jones (2675) +8 more
core
Advanced Science, EarlyView.Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo +11 more
wiley +1 more source