Results 101 to 110 of about 174,417 (293)

HPA Cell Segmentation (DPNUnet)

open access: yes, 2022
Download RDF PackageHPA Cell segmentation model This is the official baseline cell segmentation model provided to the participants of the Human Protein Atlas - Single Cell Classification competition held in 2021.
Hao Xu, Wei Ouyang
core   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun   +7 more
wiley   +1 more source

Molecular typing of human platelet antigens in immune thrombocytopenia patients in northern Brazil

open access: yesRevista Brasileira de Hematologia e Hemoterapia
Background: Immune thrombocytopenia is an immune disease characterized by thrombocytopenia and bleeding due to platelet antibodies against platelet membrane glycoproteins. Human platelet antigens are derived from polymorphisms of these glycoproteins. The
Julia Cavalcante do Carmo   +6 more
doaj   +1 more source

Delimiting affinity zones as a basis for air pollution mapping in Europe

open access: yesEnvironment International, 2013
Affinity zones are defined as areas within which air quality displays consistent behaviour over space and time. Constructed using multivariate statistical techniques and physiographic and landscape variables reflecting underlying sources and spatial ...
Danielle Vienneau, David J. Briggs
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu   +4 more
wiley   +1 more source

Análise da ocorrência dos fluxos e Jatos de Nível Baixo no perfil vertical do vento na baixa atmosfera em Manaus (AM) Analysis of the occurrence of streams and Low Level Jets in the vertical wind profile at the lower-atmosphere of Manaus city

open access: yesRevista Brasileira de Meteorologia, 2008
Este estudo apresenta uma análise sobre as estruturas verticais nos baixos níveis da atmosfera tropical, região norte do Brasil, utilizando dados de radiossondagem realizadas na cidade de Manaus.
Cleber Souza Corrêa   +3 more
doaj   +1 more source

Chaihu-Shugan-San Ameliorated Osteoporosis of Mice with Depressive Behavior Caused by Chronic Unpredictable Mild Stress via Repressing Neuroinflammation and HPA Activity

open access: yesDrug Design, Development and Therapy
Ming-Chao He,1,2,* Shi-Hui Xia,2,3,* Hao Pan,4,* Ting-Ting Zhou,5 Xin-Luan Wang,6 Ji-Ming Li,6 Xiao-Ming Li,5 Yan Zhang2,3 1Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s ...
He MC   +7 more
doaj  

长春地区无偿献血者HPA1-6,15基因分型及频率调查

open access: yesZhongguo shiyan zhenduanxue, 2011
目的调查北方汉族人群人类血小板抗原(HPA)的基因频率及分布规律。建立一支HPA-1a,-2a,-4a,-5a,-6a阴性及已知HPA抗原的献血者队伍。方法随机抽取172名长春地区固定无偿血小板捐献者静脉血3ml,枸橼酸钠抗凝;采用TIANGEN试剂盒提取DNA。基因定量仪测定DNA的浓度和纯度。采用PCR-SSP方法进行试验。最后进行统计学分析。结果各表现型的频率分别是:HPA-1aa 0.988,HPA-1ab 0.012,HPA-2aa 0.833,HPA-2ab 0.159,HPA-2bb 0 ...
于江虹, 杨帆, 焦立新, 刘铁梅
doaj  

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

open access: yesJournal of Applied Polymer Science, EarlyView.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis   +1 more
wiley   +1 more source

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