Results 101 to 110 of about 66,213 (258)

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

Therapeutic Potential of Fecal Microbiota Transplantation for Male Sexual Dysfunction: Evidence and Clinical Perspectives

Microbiota Medicine Research, EarlyView.
ABSTRACT Fecal microbiota transplantation (FMT), a microbiome‐based therapy, shows potential in treating male sexual dysfunction. Research into the influence of FMT on male sexual function has recently garnered increasing attention. This review aims to explore the impact of FMT on male sexual function and the underlying mechanisms, and to analyze the ...
Junyi Chen, Chenfeng Bu, Xia Li, Lei Wu, Xingxiang He   +4 more
wiley   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Psychological Impacts of a Teacher Mindfulness‐Based Program: Moderation by Changes in Neuroendocrine Stress Over Time

Psychology in the Schools, EarlyView.
ABSTRACT This study extends previous research on a Mindfulness Based Program (MBP) for teachers by examining whether psychological impacts of MBP participation were moderated by changes in teachers' neuroendocrine stress across the program. Teachers (n = 60, 54 women) were randomly assigned to MBP or waitlist control conditions and assessed at pre ...
Heidemarie K. Laurent, Robert W. Roeser, Kimberly A. Schonert‐Reichl   +2 more
wiley   +1 more source

Safety of 12‐Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Dynamics and model representation of two contrasting extreme precipitation events in the Sahel

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Hovmöller diagrams of the two investigated extreme precipitation events in Mali are shown for (i) IMERG observations, and ICOsahedral Nonhydrostatic model (ICON) runs with parameterization of explicit convection (ii) enabled and (iii) disabled. This work highlights that the commonly perceived benefit of using explicit convection in a state‐of‐the‐art ...
Souleymane Sanogo, Marlon Maranan, Andreas H. Fink, Beth J. Woodhams, Peter Knippertz   +4 more
wiley   +1 more source

Reelin, the HPA Axis, and Chronic Stress: Implications for the Neurobiology of Depression. [PDF]

Chronic Stress (Thousand Oaks)
Thom SA, Halvorson CS, Reive BS, Sànchez-Lafuente CL, Kalynchuk LE, Caruncho HJ.   +5 more
europepmc   +1 more source

Windows of opportunity in subseasonal weather regime forecasting: A statistical–dynamical approach

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This study explores how the atmospheric state at initialisation creates windows of opportunity for improving week 3 forecasts of weather regime activity. Greenland blocking activity increases following Madden–Julian Oscillation phases 7, 8, and 1 and weak stratospheric polar vortex states, revealing patterns exploitable by statistical models.
Fabian Mockert, Christian M. Grams, Sebastian Lerch, Julian Quinting   +3 more
wiley   +1 more source