Results 151 to 160 of about 66,213 (258)

Provider Perceptions of Perinatal Mental Healthcare Access

Birth, EarlyView.
Study methodology and conclusions: Primary barriers to care and action items for providers. ABSTRACT Background The consequences of untreated perinatal mental health conditions are well‐established, yet fewer than one in five women experiencing perinatal mental health distress receive treatment. Although recommendations for evidence‐based treatment are
Susanna Sutherland, Amanda L. Stone, Sarah S. Osmundson   +2 more
wiley   +1 more source

Comparative Analysis of HPA-Axis Dysregulation and Dynamic Molecular Mechanisms in Acute Versus Chronic Social Defeat Stress. [PDF]

Int J Mol Sci
Yang J, Jia Y, Guo T, Zhang S, Huang J, Lu H, Li L, Xu J, Liu G, Xiao K.   +9 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus-A Mini Review. [PDF]

Int J Mol Sci
Lei AA, Phang VWX, Lee YZ, Kow ASF, Tham CL, Ho YC, Lee MT.   +6 more
europepmc   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Exploring individual differences in fear extinction in male and female mice: insights from HPA axis, microbiota, and transcriptomics. [PDF]

Transl Psychiatry
Ten-Blanco M, Ponce-Renilla M, Pereda-Pérez I, Izquierdo-Luengo C, Bressa C, Zafra O, Tolón RM, Berrendero F.   +7 more
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Prefrontal cortex stimulation prevents stress-induced HPA axis reactivity in people at familial risk of schizophrenia. [PDF]

Eur Psychiatry
Adam O, Perret M, Simon L, Dondé C, Raverot V, Vallet W, Mondino M, Brunelin J.   +7 more
europepmc   +1 more source

The Overlooked Autoantibody Repertoire: Exploring the Biomarker Potential of Downregulated Autoantibodies in NSCLC

Cancer Science, EarlyView.
This study identifies downregulated autoantibodies in NSCLC and demonstrates their diagnostic and prognostic utility. Integrating proteome‐wide screening and large‐cohort validation, we highlight a novel biomarker class that enhances early detection and patient stratification.
Yihao Liang, Hanke Ma, Wenke Sun, Ying Chen, Fengqi Chen, Yutong Li, Songyun Ouyang, Liping Dai   +7 more
wiley   +1 more source