Results 151 to 160 of about 802,913 (283)

Sex-specific mechanisms of childhood trauma-related HPA axis dysregulation: Insights across four regulatory probes. [PDF]

Psychoneuroendocrinology
Hinchey LM, Abelson JL.
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

From the TPR pathway and the neuroimmune unit to the cutaneous HPA axis: a neuro-endo-immune cross-talk in rosacea. [PDF]

Front Med (Lausanne)
He Z, Feng YY, Ning T, Wu P, Yang C, Zhang Q.   +5 more
europepmc   +1 more source

Atopic dermatitis and attention‐deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management

Pediatric Investigation, EarlyView.
This review synthesizes epidemiological evidence linking atopic dermatitis to attention‐deficit/hyperactivity disorder in children, proposes an “inflammation‐itch‐neurobehavioral axis” integrating sleep disruption, neuroendocrine dysregulation, and emerging neuro‐immune circuits, and outlines multidisciplinary management strategies targeting both skin ...
Qingyang Zhao, Yuan Liang, Ying Liu, Chunping Shen, Mutong Zhao, Jing Tian, Lei Jiao, Jing Sun, Ying Gu, Qiong Wu, Shan Wang, Lin Ma   +11 more
wiley   +1 more source

Chronic stress, cortisol dysregulation, and neurodegenerative vulnerability: mechanistic pathways linking HPA-axis dysfunction to Alzheimer's disease risk. [PDF]

Front Aging Neurosci
Almalki DF, Alkabkabi RA, Wayyani RA, Alharthi AS, Aljuhani HA, Mahyub RM, Bakhsh HS, Alomani AM, Almhmadi NN, Aljohani AA, Tawakul AA.   +10 more
europepmc   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Intermittent Fasting Exerts Antidepressant-Like Effects by Restoring HPA Axis Homeostasis Through Coordinated GR-MR Signaling. [PDF]

FASEB J
Tang M, Sun Q, Song J, Piao X, Geng Z, Han X, Li R, Li Y, Han M, Cui R, Li B.   +10 more
europepmc   +1 more source

The role of the synoptic‐scale conditions in driving fog and mist during the FATIMA July 2022 Sable Island Field program

Quarterly Journal of the Royal Meteorological Society, EarlyView.
ERA5 hourly 325‐m and 1512‐m (a) convergence and (b) vertical motion (actually pressure change with sign reversed to compare with convergence) over Sable Island around the time of an event. The mist (green) and fog (red) occurrences at the surface station are shown at the bottom of the figures. A 325‐m fitted line convergence was positive for the first
Clive E. Dorman, Darko Koračin, Reneta Dimitrova, Ismail Gultepe, Sebastian W. Hoch, Jesus Ruiz‐Plancarte, Qing Wang, Alexei Perelet, H. J. S. Fernando   +8 more
wiley   +1 more source

Androgen loss accelerates brain tumour growth via HPA axis activation. [PDF]

Nature
Lee J, Chung YM, Silver DJ, Hao Y, Harwood DSL, Ealy A, Serapiglia AM, Curtin L, Benedetti JR, Ballard CAP, Lapsley K, Alvarez-Vazquez A, Goldberg J, Li C, Kaur S, Neal R, Wang SZ, Kay KE, Volovetz J, Hong ES, Fodor R, Jarmula J, Nicosia M, Rubin JB, Swanson KR, Ostrom QT, Panicker N, Kristensen BW, Berens M, Sharifi N, Lathia JD.   +30 more
europepmc   +1 more source

Spatial observation‐error correlations for AMSU‐A in all‐sky assimilation: An ECMWF and UK Met Office intercomparison

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Assimilation of AMSU‐A all‐sky observations can be increased up to fivefold if spatial observation‐error correlations are accounted for properly. New correlation estimates derived using data from ECMWF and the UK Met Office reveal that correlation length‐scales are between 75 and 150 km for AMSU‐A channels peaking in the troposphere. This is attributed
Rishabh Bhatt, Massimo Bonavita, Niels Bormann, Sarah L. Dance, Alison Fowler, Elías Hólm, Christopher J. Merchant, Jonathan Mittaz, Stuart Newman, Joanne Waller   +9 more
wiley   +1 more source