Pathological and virological findings of type I interferon receptor knockout mice upon experimental infection with Heartland virus [PDF]
Virus ResearchHeartland virus (HRTV) causes generalized symptoms, severe shock, and multiple organ failure. We previously reported that interferon-α/β receptor knockout (IFNAR-/-) mice infected intraperitoneally with 1 × 107 tissue culture-infective dose (TCID50) of ...
Hikaru Fujii +18 more
doaj +2 more sources
Heartland Virus Disease—An Underreported Emerging Infection [PDF]
MicroorganismsFirst recognized 15 years ago, Heartland virus disease (Heartland) is a tickborne infection contracted from the transmission of Heartland virus (HRTV) through tick bites from the lone star tick (Amblyomma americanum) and potentially other tick species ...
Zygmunt F. Dembek +3 more
doaj +2 more sources
Vertebrate Host Susceptibility to Heartland Virus [PDF]
Emerging Infectious Diseases, 2016 Heartland virus (HRTV) is a recently described phlebovirus initially isolated in 2009 from 2 humans who had leukopenia and thrombocytopenia. Serologic assessment of domestic and wild animal populations near the residence of 1 of these persons showed high
Angela M. Bosco-Lauth +8 more
doaj +3 more sources
Geographical distribution and pathogenesis of ticks and tick-borne viral diseases [PDF]
Frontiers in Microbiology, 2023 Ticks are obligatory hematophagous arthropods that harbor and transmit infectious pathogens to humans and animals. Tick species belonging to Amblyomma, Ixodes, Dermacentor, and Hyalomma genera may transmit certain viruses such as Bourbon virus (BRBV ...
Taif Shah +9 more
doaj +2 more sources
Influence of N-Glycosylation on Virus–Host Interactions in Halorubrum lacusprofundi [PDF]
Viruses, 2023 N-glycosylation is a post-translational modification of proteins that occurs across all three domains of life. In Archaea, N-glycosylation is crucial for cell stability and motility, but importantly also has significant implications for virus–host ...
L. Johanna Gebhard +4 more
doaj +2 more sources
Widespread Circulation of Tick-Borne Viruses in Virginia—Evidence of Exposure to Heartland, Bourbon, and Powassan Viruses in Wildlife and Livestock [PDF]
MicroorganismsEmerging tick-borne viruses such as Powassan virus (POWV), Bourbon virus (BRBV), and Heartland virus (HRTV), whilst rare, can cause severe health problems in humans.
Ahmed Garba +3 more
doaj +2 more sources
Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA. [PDF]
Ticks Tick Borne Dis, 2023 Heartland and Bourbon viruses are pathogenic tick-borne viruses putatively transmitted by Amblyomma americanum, an abundant tick species in Missouri. To assess the prevalence of these viruses in ticks, we collected 2778 ticks from eight sampling sites at
Aziati ID +9 more
europepmc +3 more sources
Dermatological manifestations of tick-borne viral infections found in the United States [PDF]
Virology Journal, 2022 Tick-borne diseases (TBDs) are bacterial, viral, and parasitic diseases transmitted by ticks. Viral TBDs have increased in prevalence over the last decade with many new pathogenic viruses being discovered.
Ammie Rupani +2 more
doaj +2 more sources
Current insights into human pathogenic phenuiviruses and the host immune system [PDF]
VirulencePhenuiviruses are a class of segmented negative-sense single-stranded RNA viruses, typically consisting of three RNA segments that encode four distinct proteins. The emergence of pathogenic phenuivirus strains, such as Rift Valley fever phlebovirus (RVFV)
Chuan-Min Zhou +3 more
doaj +2 more sources
Comparison between available early antiviral treatments in outpatients with SARS-CoV-2 infection: a real-life study. [PDF]
BMC Infect Dis, 2023 Purpose: To investigate the clinical impact of three available antivirals for early COVID-19 treatment in a large real-life cohort. Methods: Between January and October 2022 all outpatients tested positive for SARS-CoV-2 referring to IRCCS S.
Rinaldi M +16 more
europepmc +3 more sources