Results 141 to 150 of about 9,646 (179)

Small Heat Shock Proteins HSP27 and αB-Crystallin: Cytoprotective and Oncogenic Functions

Antioxidants and Redox Signaling, 2005
Heat shock protein-27 (HSP27) and alphaB-crystallin are ubiquitous small heat shock proteins whose expression is induced in response to a wide variety of physiological and environmental insults. They allow the cells to survive in otherwise lethal conditions.
Eric Solary, Carmen Garrido, Arlette Hammann   +2 more
exaly   +3 more sources

Enhanced stability of αB-crystallin in the presence of small heat shock protein Hsp27

Biochemical and Biophysical Research Communications, 2003
Lens alpha-crystallin, alpha A- and alpha B-crystallin, and Hsp27 are members of the small heat shock protein family. Both alpha A- and alpha B-crystallin are expressed in the lens and serve as structural proteins and as chaperones, but alpha B-crystallin is also expressed in nonlenticular organs where Hsp27, rather than alpha A-crystallin, is ...
Jack J-N Liang, Jack J -N Liang
exaly   +3 more sources

Synthetic study of phosphopeptides related to heat shock protein HSP27

Bioorganic & Medicinal Chemistry, 1997
Two kinds of phosphoserine-containing peptides related to HSP27 were synthesized by the Boc- or Fmoc-mode solid-phase method based on prephosphorylation strategy. In the case of the Boc strategy, the O-phosphono group of the phosphoserine residue was protected with the cyclopentyl or cyclohexyl group.
T, Wakamiya, R, Togashi, T, Nishida, K, Saruta, J, Yasuoka, S, Kusumoto, S, Aimoto, K Y, Kumagaye, K, Nakajima, K, Nagata   +9 more
openaire   +2 more sources

The small heat shock protein Hsp27: Present understanding and future prospects

Journal of Thermal Biology, 2017
Heat shock proteins are important for maintaining protein homeostasis and cell survival. Among different classes of highly conserved Hsps, low molecular weight Hsps (sHsps) have significant place, particularly Hsp27, whose role has been demonstrated in wide range of biological processes, including development, immunity, diseases and therapy.
Manish Kumar, Singh, Bechan, Sharma, Pramod K, Tiwari   +2 more
openaire   +2 more sources

Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review

JNCI Journal of the National Cancer Institute, 1993
Heat shock and other environmental and pathophysiologic stresses stimulate synthesis of heat shock proteins (Hsps). These proteins enable the cell to survive and recover from stressful conditions by as yet uncompletely understood mechanisms. Hsp27 is an important small Hsp (molecular weight, 27,000) found in human cells--both cancer cells and normal ...
D R, Ciocca, S, Oesterreich, G C, Chamness, W L, McGuire, S A, Fuqua   +4 more
openaire   +2 more sources

Heat Shock Proteins (HSP70 and HSP27) as Markers of Epithelial Dysplasia in Oral Leukoplakia

The American Journal of Dermatopathology, 2006
Heat shock proteins (HSPs) play a significant role in cell proliferation, differentiation, and oncogenesis. HSP70 and HSP27 are constitutively and gradually expressed in a broad range of normal tissues and neoplasms, and their expression has been assessed as markers for oral epithelial dysplasia. The study involved 43 patients with oral leukoplakia (OL)
Juan M, Seoane, Pablo I, Varela-Centelles, José R, Ramirez, José, Cameselle-Teijeiro, Maria A, Romero, José Manuel, Aguirre   +5 more
openaire   +2 more sources

Detection of the Soluble Heat Shock Protein 27 (hsp27) in Human Serum by an ELISA

Journal of Immunoassay and Immunochemistry, 2004
Increased levels of autoantibodies against heat shock protein 27 (hsp27) in patients with breast, ovarian, or endometrial cancer strongly suggest the presence and increased levels of hsp27 in their circulation. Therefore, we have developed a sensitive and reproducible ELISA for quantification of soluble hsp27 levels in biological fluid such as serum ...
Asit K, De, Sarah E, Roach
openaire   +2 more sources

Tissue-Specific Posttranslational Modification of the Small Heat Shock Protein HSP27 inDrosophila

Experimental Cell Research, 1996
Drosophila sHSPs (small heat shock proteins) are expressed in the absence of stress in specific regions of the central nervous system and in gonads of young adults flies. In these two organs, the sHSPs show a cell-specific and developmental stage-specific pattern of expression suggesting distinct regulation and function(s) of each individual sHSP (R ...
R, Marin, J, Landry, R M, Tanguay
openaire   +2 more sources

Endoplasmic reticulum stress induces the phosphorylation of small heat shock protein, Hsp27

Journal of Cellular Biochemistry, 2005
AbstractThere are several reports describing participation of small heat shock proteins (sHsps) in cellular protein quality control. In this study, we estimated the endoplasmic reticulum (ER) stress‐induced response of Hsp27 and αB‐crystallin in mammalian cells.
Hidenori, Ito, Ikuko, Iwamoto, Yutaka, Inaguma, Takenori, Takizawa, Koh-ichi, Nagata, Tomiko, Asano, Kanefusa, Kato   +6 more
openaire   +2 more sources

Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis

Gastroenterology, 2004
Heat shock protein (Hsp) 27 regulates actin cytoskeletal dynamics, and overexpression of Hsp27 in fibroblasts protects against stress in a phosphorylation-dependent manner. Induction of Hsps occurs in acute pancreatitis, but Hsp27 has not been ascribed a specific role.
Constanze, Kubisch, Matthew J, Dimagno, Anne Barbara, Tietz, Michael J, Welsh, Stephen A, Ernst, Barbara, Brandt-Nedelev, Joachim, Diebold, Andreas C C, Wagner, Burkhard, Göke, John A, Williams, Claus, Schäfer   +10 more
openaire   +2 more sources