Results 151 to 160 of about 9,646 (179)

Heat Shock Proteins Hsp70 and Hsp27 and Neural Cellular Protection

2008
Heat shock proteins (Hsps) are expressed throughout the body. In the brain, the 27,kDa Hsp, Hsp27, and the 71–72,kDa Hsp, Hsp70, are expressed and can be protective against many stressors. Following cellular stress and injury including inflammation, ischemia, and seizures, Hsp27 and Hsp70 are induced to high levels and can protect cells from further ...
Tracy S. Voegeli, Amanda J. Wintink, R. William Currie   +2 more
openaire   +1 more source

Heat-shock-protein-27(HSP27) expression in ovarian carcinoma: Relation in response to chemotherapy and prognosis

International Journal of Cancer, 1999
Heat-shock protein 27 (hsp27) is one of the small heat-shock proteins. Its expression in ovarian- and breast-cancer cell lines has been associated with resistance to cisplatin and doxorubicin. In addition, hsp27 expression appears to facilitate cellular growth, differentiation and motility.
Arts, HJG, Hollema, H, Lemstra, W, Willemse, PHB, De Vries, EGE, Kampinga, HH, Van der Zee, AGJ   +6 more
openaire   +3 more sources

Differential Expression of Small Heat Shock Protein 27 (Hsp27) in Ataxia telangiectasia Brains

Neurochemical Research, 2009
Ataxia telangiectasia (A-T) is a progressive neurodegenerative disorder caused by disruption of the gene, ataxia telangiectasia mutated (ATM). Present study was aimed at identifying proteins that are present in abnormal levels in A-T brain that may identify alternative targets for therapeutic interventions.
Wenqiang, Chen, Salomon, Kuizon, Bair L, Chiou, David C, Bolton, Raju K, Pullarkat, Mohammed A, Junaid   +5 more
openaire   +2 more sources

Differential expression of heat shock protein HSP27 in human neurons and glial cells in culture

Journal of Neuroscience Research, 1995
AbstractHSP27 expression was investigated in cultured neurons and glial cells isolated from fetal human brains using immunoblotting and immunocytochemistry. Under unstressed conditions, HSP27 was identified at a high level in astrocytes (>99%), at a low level in neurons (7%), and at a minimally detectable level in microglia (<1%), whereas it was ...
J I, Satoh, S U, Kim
openaire   +2 more sources

Developmentally regulated gene expression of the small heat shock protein Hsp27 in zebrafish embryos

Gene Expression Patterns, 2006
Mammalian small heat shock proteins including Hsp27 and alpha-B crystallin are constitutively expressed in various adult and embryonic tissues including skeletal and cardiac muscle. However, the function of these proteins during embryonic development is not understood, and information on their expression during the earliest stages of development is ...
L, Mao, E A, Shelden
openaire   +2 more sources

Expression of the heat shock protein HSP27 in human ovarian cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
The relationship of the heat shock protein HSP27 in ovarian cancer to several biological and clinical parameters was investigated in a series of primary tumors and cell lines. Analysis of 72 primary tumors (54 malignant, 5 borderline, and 13 benign neoplasms) indicated that malignant tumors expressed higher HSP27 concentrations than benign tumors ...
S P, Langdon, G J, Rabiasz, G L, Hirst, R J, King, R A, Hawkins, J F, Smyth, W R, Miller   +6 more
openaire   +1 more source

Small Heat Shock Protein 27 (HSP27) Associates with Tubulin/Microtubules in HeLa Cells

Biochemical and Biophysical Research Communications, 2000
One of the monoclonal antibodies raised against mitotic HeLa cells (termed as mH3) recognized a 27-kDa protein and stained microtubules in the mitotic spindles of HeLa cells. Immunoscreening of a HeLa cDNA library revealed that mH3 antigen is a small heat shock protein, HSP27.
M, Hino, K, Kurogi, M A, Okubo, M, Murata-Hori, H, Hosoya   +4 more
openaire   +2 more sources

Sudden infant death syndrome: no significant expression of heat-shock proteins (HSP27, HSP70)

Forensic Science, Medicine, and Pathology, 2015
In industrialized countries, sudden infant death is the most common cause of death in young children. Although prone sleeping position is a well-known risk factor, hyperthermia might also be important. Pathognomonic findings of premortem hyperthermia do not exist.
Elke, Doberentz, Sarah, Führing, Burkhard, Madea   +2 more
openaire   +2 more sources

Subcorneal colocalization of the small heat shock protein, hsp27, with keratins and proteins of the cornified cell envelope

British Journal of Dermatology, 2002
hsp27 is a member of the small heat shock protein family. Its expression in epidermal keratinocytes in situ and in tissue culture correlates with differentiation. Experimental evidence points to the fact that hsp27 is a molecular chaperone and is involved in the regulation of cell growth and differentiation.To investigate whether epidermal hsp27 ...
C, Jonak, G, Klosner, C, Kokesch, D, FOdinger, H, HOnigsmann, F, Trautinger   +5 more
openaire   +2 more sources

Small heat shock proteins Hsp27 or αB‐crystallin and the protein components of neurofibrillary tangles: Tau and neurofilaments

Journal of Neuroscience Research, 2007
AbstractThe heat‐shock proteins (HSPs) Hsp27 and αB‐crystallin are up‐regulated in Alzheimer's disease (AD), but the extent of this and the consequences are still largely unknown. The HSPs are involved in protein degradation and protection against protein aggregation, and they interact with several cytoskeletal components such as microtubules (MT) and ...
Bjorkdahl, C., Sjogren, J.M.C., Zhou, X., Concha, H., Avila, J., Winblad, B., Pei, J.J.   +6 more
openaire   +4 more sources