Results 171 to 180 of about 3,351,166 (211)

Heat shock proteins HSP27, HSP60, HSP70, and HSP90 [PDF]

Cancer, 2003
AbstractBACKGROUNDHeat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in neoplasia has been implicated in the regulation of apoptosis, and HSPs also can act by increasing immunity. In the current study, the authors attempted to clarify the significance of HSPs in
Thierry LEBRET, Vincent Molinie, R William G Watson   +2 more
exaly   +3 more sources

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Synthetic study of phosphopeptides related to heat shock protein HSP27

Bioorganic & Medicinal Chemistry, 1997
Two kinds of phosphoserine-containing peptides related to HSP27 were synthesized by the Boc- or Fmoc-mode solid-phase method based on prephosphorylation strategy. In the case of the Boc strategy, the O-phosphono group of the phosphoserine residue was protected with the cyclopentyl or cyclohexyl group.
T, Wakamiya, R, Togashi, T, Nishida, K, Saruta, J, Yasuoka, S, Kusumoto, S, Aimoto, K Y, Kumagaye, K, Nakajima, K, Nagata   +9 more
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Heat shock proteins HSP27 and HSP70 in unilateral obstructed kidneys

Pediatric Nephrology, 2003
Unilateral ureteropelvic junction obstruction (UPJO), a condition involving injury to the kidney, leads to vasoconstriction, macrophage infiltration, oxidative stress, and tubulointerstitial fibrosis. In the present study we analyzed in 22 children, the impact of UPJO on expression of HSP27 and HSP70 and related the changes to renal function and ...
Patricia, Vallés, Facundo, Jorro, Liliana, Carrizo, Walter, Manucha, Julio, Oliva, F Darío, Cuello-Carrión, Daniel R, Ciocca   +6 more
openaire   +2 more sources

Enhanced stability of αB-crystallin in the presence of small heat shock protein Hsp27

Biochemical and Biophysical Research Communications, 2003
Lens alpha-crystallin, alpha A- and alpha B-crystallin, and Hsp27 are members of the small heat shock protein family. Both alpha A- and alpha B-crystallin are expressed in the lens and serve as structural proteins and as chaperones, but alpha B-crystallin is also expressed in nonlenticular organs where Hsp27, rather than alpha A-crystallin, is ...
Jack J-N Liang, Jack J -N Liang
exaly   +3 more sources

Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review

JNCI Journal of the National Cancer Institute, 1993
Heat shock and other environmental and pathophysiologic stresses stimulate synthesis of heat shock proteins (Hsps). These proteins enable the cell to survive and recover from stressful conditions by as yet uncompletely understood mechanisms. Hsp27 is an important small Hsp (molecular weight, 27,000) found in human cells--both cancer cells and normal ...
D R, Ciocca, S, Oesterreich, G C, Chamness, W L, McGuire, S A, Fuqua   +4 more
openaire   +2 more sources

The taming of small heat-shock proteins: crystallization of the α-crystallin domain from human Hsp27 [PDF]

Acta Crystallographica Section F: Structural Biology Communications, 2009
Small heat-shock proteins (sHsps) are ubiquitous molecular chaperones. sHsps function as homooligomers or heterooligomers that are prone to subunit exchange and structural plasticity. Here, a procedure for obtaining diffraction-quality crystals of the alpha-crystallin domain of human Hsp27 is presented.
Sergei V Strelkov, N B Gusev
exaly   +3 more sources

The small heat shock protein Hsp27: Present understanding and future prospects

Journal of Thermal Biology, 2017
Heat shock proteins are important for maintaining protein homeostasis and cell survival. Among different classes of highly conserved Hsps, low molecular weight Hsps (sHsps) have significant place, particularly Hsp27, whose role has been demonstrated in wide range of biological processes, including development, immunity, diseases and therapy.
Manish Kumar, Singh, Bechan, Sharma, Pramod K, Tiwari   +2 more
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Heat Shock Proteins (HSP70 and HSP27) as Markers of Epithelial Dysplasia in Oral Leukoplakia

The American Journal of Dermatopathology, 2006
Heat shock proteins (HSPs) play a significant role in cell proliferation, differentiation, and oncogenesis. HSP70 and HSP27 are constitutively and gradually expressed in a broad range of normal tissues and neoplasms, and their expression has been assessed as markers for oral epithelial dysplasia. The study involved 43 patients with oral leukoplakia (OL)
Juan M, Seoane, Pablo I, Varela-Centelles, José R, Ramirez, José, Cameselle-Teijeiro, Maria A, Romero, José Manuel, Aguirre   +5 more
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Detection of the Soluble Heat Shock Protein 27 (hsp27) in Human Serum by an ELISA

Journal of Immunoassay and Immunochemistry, 2004
Increased levels of autoantibodies against heat shock protein 27 (hsp27) in patients with breast, ovarian, or endometrial cancer strongly suggest the presence and increased levels of hsp27 in their circulation. Therefore, we have developed a sensitive and reproducible ELISA for quantification of soluble hsp27 levels in biological fluid such as serum ...
Asit K, De, Sarah E, Roach
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Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis

Gastroenterology, 2004
Heat shock protein (Hsp) 27 regulates actin cytoskeletal dynamics, and overexpression of Hsp27 in fibroblasts protects against stress in a phosphorylation-dependent manner. Induction of Hsps occurs in acute pancreatitis, but Hsp27 has not been ascribed a specific role.
Constanze, Kubisch, Matthew J, Dimagno, Anne Barbara, Tietz, Michael J, Welsh, Stephen A, Ernst, Barbara, Brandt-Nedelev, Joachim, Diebold, Andreas C C, Wagner, Burkhard, Göke, John A, Williams, Claus, Schäfer   +10 more
openaire   +2 more sources