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Hsp70 in Redox Homeostasis [PDF]
Cells, 2022 Cellular redox homeostasis is precisely balanced by generation and elimination of reactive oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and DNA to damage cells but can also act as signaling molecules to modulate
Hong Zhang +3 more
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HSP70 Multi-Functionality in Cancer [PDF]
Cells, 2020 The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor ...
Zarema Albakova +4 more
semanticscholar +4 more sources
Kaliandra honey improves testosterone levels, diameter and epithelial thickness of seminiferous tubule of white rat (Rattus norvegicus) due to malnutrition through stimulation of HSP70 [PDF]
Open Veterinary Journal, 2021 Background: Malnutrition can cause an increase in oxidative stress as it triggers the expression of Heat Shock Protein70 (HSP70), a chaperon molecule that is needed to repair damaged cells within optimal levels.
Nefranindy Rahma +5 more
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Hsp70, in Combination with IL-15 and PD-1 Blocker, Interferes with The Induction of Cytotoxic NK Cells in Relapsed Acute Myeloid Leukemia Patients [PDF]
Cell Journal, 2023 Objective: Natural killer (NK) cells are critical immune cells for acute myeloid leukemia (AML) targeting. However,little is known about the relationship between using checkpoint inhibitors and heat shock protein 70 (Hsp70) as NK cellactivators to ...
Javad Firouzi +8 more
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Medicine Science, 2023 Cervical and ovarian cancer are two aggressive neoplasms for women, still with high mortality and morbidity. Among the molecules and compounds that have anticancer activity, it was studied the JG-98, a heat shock protein 70 (HSP70) inhibitor.
Nazan Yurtcu +4 more
doaj +1 more source
Interplay between RNA interference and heat shock response systems in Drosophila melanogaster [PDF]
Open Biology, 2016 The genome expression pattern is strongly modified during the heat shock response (HSR) to form an adaptive state. This may be partly achieved by modulating microRNA levels that control the expression of a great number of genes that are embedded within ...
S. Yu Funikov +9 more
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Frontiers in Oncology, 2022 HSP70 and HSP90 are two powerful chaperone machineries involved in survival and proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 perform specific functions.
Zarema Albakova +3 more
semanticscholar +1 more source
Applied Sciences, 2022 Silver is back in vogue today as this metal is used in the form of nanomaterials in numerous commercial products. We have developed in-gel electrophoretic techniques to measure the activity of the antioxidant enzymes catalase (CAT), superoxide dismutase (
Candida Lorusso +3 more
doaj +1 more source
Italian Journal of Animal Science, 2021 The effects of in ovo injection of Arthrospira (Spirulina) Platensis on hatchability, antioxidant and immunity-related genes expression, and hatchling performance of broilers and Japanese quails was assessed in 2 separate experiments.
Hosna Hajati +4 more
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Dynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes [PDF]
Structure, 2016 Protein misfolding and aggregation are pathological events that place a significant amount of stress on the maintenance of protein homeostasis (proteostasis). For prevention and repair of protein misfolding and aggregation, cells are equipped with robust mechanisms that mainly rely on molecular chaperones.
Thomas Reid, Alderson +2 more
openaire +2 more sources