Results 41 to 50 of about 111,857 (291)

Changes of cellular stress response related hsp70 and abcb1 transcript and Hsp70 protein levels in Siberian freshwater amphipods upon exposure to cadmium chloride in the lethal concentration range [PDF]

PeerJ, 2020
The induction of cellular stress response systems, heat shock protein hsp70/Hsp70 and multixenobiotic transporter abcb1, by cadmium chloride (CdCl2) was explored in amphipod species with different stress adaptation strategies from the Lake Baikal area ...
Marina V. Protopopova, Vasiliy V. Pavlichenko, Till Luckenbach   +2 more
doaj   +2 more sources

Novel Signal Transduction Pathway Utilized by Extracellular HSP70

Journal of Biological Chemistry, 2002
Recent studies have initiated a paradigm shift in the understanding of the function of heat shock proteins (HSP). It is now clear that HSP can and do exit mammalian cells, interact with cells of the immune system, and exert immunoregulatory effects.
A. Asea, M. Rehli, E. Kabingu, J. A. Boch, Olivia Baré, P. Auron, M. Stevenson, S. Calderwood   +7 more
semanticscholar   +1 more source

Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic mice [PDF]

Cell Stress and Chaperones, 2014
The aim of this study was to investigate the potential protective effect of the Hsp70 protein in the cardiac dysfunction induced by doxorubicin (DOX) and the mechanisms of its action. For this purpose, we used both wild-type mice (F1/F1) and Hsp70-transgenic mice (Tg/Tg) overexpressing human HSP70.
Katerina, Naka K, Patra, Vezyraki, Alexandros, Kalaitzakis, Stelios, Zerikiotis, Lampros, Michalis, Charalampos, Angelidis   +5 more
openaire   +2 more sources

Maintenance of the Expression of c-FLIPL by Hsp70 to Resist Licochalcone A-Induced Anti-Colorectal Cancer Effect through ERK-Mediated Autophagy Induction

Frontiers in Bioscience-Landmark, 2023
Background: The mortality rate of colorectal cancer (CRC) ranks second worldwide. Previous research had indicated that licochalcone A (LA) was a flavonoid in licorice with diverse anticancer effects.
Tianpeng Li, Ting Li, Hongbin Zhang, Chunyan Liu, Min Li, Chu Wang, Yuanyuan Zheng, Lihua Zhang, Xiaoyi Long, Shaoqing Shi, Yun Long, Wei Chen   +11 more
doaj   +1 more source

The relationship between HSP70 and level of leptin and luteinizing hormones in female rats exposed to chronic and acute heat stress [PDF]

Iraqi Journal of Veterinary Sciences, 2020
The current search experiments designed to study the effect of chronic and acute heat stress on the relationship between HSP70, leptin and luteinizing hormones level in female rats.
Hiyam N. Matty, Ashwaq A. Hassan
doaj   +1 more source

Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones

Journal of Biological Chemistry, 2018
Hsp70 chaperones are central hubs of the protein quality control network and collaborate with co-chaperones having a J-domain (an ∼70-residue–long helical hairpin with a flexible loop and a conserved His–Pro–Asp motif required for ATP hydrolysis by ...
M. Mayer, L. Gierasch
semanticscholar   +1 more source

Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes [PDF]

Cell Stress and Chaperones, 2016
The cellular response to stress is orchestrated by the expression of a family of proteins termed heat shock proteins (hsp) that are involved in the stabilization of basic cellular processes to preserve cell viability and homeostasis. The bulk of hsp function occurs within the cytosol and subcellular compartments.
Victor, Lopez, David M, Cauvi, Nelson, Arispe, Antonio, De Maio   +3 more
openaire   +2 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Φλαβονοειδή και Hsp70

, 2023
Οι HSP70 ανήκουν στην οικογένεια των μοριακών συνοδών, αποτελούν πρωτεΐνες θερμικού σοκ πανταχού παρούσες σε όλους τους οργανισμούς, και η υπερέκφραση τους επάγεται από ερεθίσματα κυτταρικού στρες. Σε μοριακό επίπεδο εξασφαλίζουν την πρωτεϊνική ομοιόσταση, σε κυτταρικό επίπεδο ελέγχουν διάφορα αποπτωτικά σηματοδοτικά μονοπάτια, ενώ σε επίπεδο ...
openaire   +3 more sources

HSP70 promotes MLKL polymerization and necroptosis

Molecular & Cellular Oncology, 2020
Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 ...
Andrea N. Johnston, Zhigao Wang
doaj   +1 more source