Results 51 to 60 of about 158,688 (339)
Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic mice [PDF]
Cell Stress and Chaperones, 2014 The aim of this study was to investigate the potential protective effect of the Hsp70 protein in the cardiac dysfunction induced by doxorubicin (DOX) and the mechanisms of its action. For this purpose, we used both wild-type mice (F1/F1) and Hsp70-transgenic mice (Tg/Tg) overexpressing human HSP70.
Katerina, Naka K +5 more
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The relationship between HSP70 and level of leptin and luteinizing hormones in female rats exposed to chronic and acute heat stress [PDF]
Iraqi Journal of Veterinary Sciences, 2020 The current search experiments designed to study the effect of chronic and acute heat stress on the relationship between HSP70, leptin and luteinizing hormones level in female rats.
Hiyam N. Matty, Ashwaq A. Hassan
doaj +1 more source
Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes [PDF]
Cell Stress and Chaperones, 2016 The cellular response to stress is orchestrated by the expression of a family of proteins termed heat shock proteins (hsp) that are involved in the stabilization of basic cellular processes to preserve cell viability and homeostasis. The bulk of hsp function occurs within the cytosol and subcellular compartments.
Victor, Lopez +3 more
openaire +2 more sources
, 2023 Οι HSP70 ανήκουν στην οικογένεια των μοριακών συνοδών, αποτελούν πρωτεΐνες θερμικού σοκ πανταχού παρούσες σε όλους τους οργανισμούς, και η υπερέκφραση τους επάγεται από ερεθίσματα κυτταρικού στρες. Σε μοριακό επίπεδο εξασφαλίζουν την πρωτεϊνική ομοιόσταση, σε κυτταρικό επίπεδο ελέγχουν διάφορα αποπτωτικά σηματοδοτικά μονοπάτια, ενώ σε επίπεδο ...
openaire +3 more sources
Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]
, 2014 The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher +3 more
core +2 more sources
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]
, 2020 Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan +10 more
core +1 more source
The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells
Vaccine Research, 2020 Introduction: Vaccine design is mainly considered as a therapeutic strategy to elicit HIV-specific immunity. DNA vaccines encoding an antigen and also an adjuvant can induce an effective adaptive immunity. Due to having numerous roles in viral infection,
Alireza Milani +3 more
doaj
Medicine Science, 2022 The goal of this research was to investigate at the expression profiles of heat shock protein 70 (HSP70) and receptor activator of nuclear factor-kappa B ligand (RANKL) in term and preterm infants.
Baris Uzunok, Selcuk Gurel
doaj +1 more source
Mitochondrial molecular chaperones [PDF]
, 1994 After synthesis in the cytosol, most mitochondrial proteins must traverse mitochondrial membranes to reach their functional location. During this process, proteins become unfolded and then refold to attain their native conformation after crossing the ...
Atencio +32 more
core +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source