Results 61 to 70 of about 111,857 (291)

A Soft Microrobot for Single‐Cell Transport, Spheroid Assembly, and Dual‐Mode Drug Screening

Advanced Materials, EarlyView.
A soft, untethered hydrogel microrobot enables precise single‐cell delivery, self‐assembly into 3D spheroids, and real‐time thermal actuation. Driven by light‐induced convection and embedded with gold nanorods and temperature sensors, the microrobot guides cells, modulates local microenvironments, and supports drug testing.
Philipp Harder, Nergishan İyisan, Yukun Wang, Berna Özkale   +3 more
wiley   +1 more source

The hsp70 new functions as a regulator of reproduction both female and male in Ophraella communa

Frontiers in Molecular Biosciences, 2022
Heat shock proteins (Hsps) function as molecular chaperones that enable organisms to withstand stress and maintain normal life activities. In this study, we identified heat shock protein 70 (encoded by hsp70), which exhibits a higher expression in the ...
Yan Zhang, Weihua Ma, Chao Ma, Qinglu Zhang, Zhenya Tian, Zhenya Tian, Zhenqi Tian, Hongsong Chen, Hongsong Chen, Jianying Guo, Fanghao Wan, Zhongshi Zhou, Zhongshi Zhou   +12 more
doaj   +1 more source

HSP70 is a negative regulator of NLRP3 inflammasome activation

Cell Death and Disease, 2019
The NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome is a multi-protein complex, aimed at producing IL-1β in response to danger signals which must be tightly regulated.
P. Martine, Angélique Chevriaux, V. Derangère, L. Apetoh, C. Garrido, F. Ghiringhelli, C. Rébé   +6 more
semanticscholar   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1

eLife, 2019
Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones negatively regulate the activity of Hsf1 via stress-responsive mechanisms that
Anna E. Masser, Wenjing Kang, Joydeep Roy, J. M. Kaimal, J. Quintana-Cordero, M. Friedländer, C. Andréasson   +6 more
semanticscholar   +1 more source

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Primer informe de Leishmania naiffi en Zamora Chinchipe (Ecuador) utilizando el gen que codifica la proteína HSP70

Cedamaz, 2021
En Ecuador se encuentran informadas algunas de las especies de Leishmania pertenecientes al subgénero Viannia (V), causante de enfermedades como leishmaniasis cutánea, cutánea difusa no curativa y mucocutánea. El objetivo de este trabajo fue diagnosticar
Luis Alberto Morocho-Yaguana, Gina Stefany Jaramillo-Balcázar, Franklin Román-Cárdenas, Loidy Zamora-Gutiérrez   +3 more
doaj  

Hsp70- and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants.

Molecules and Cells, 2019
The activity of the tumor suppressor p53 has to be timed and balanced closely to prevent untimely induction of cell death. The stability of p53 depends on the ubiquitin ligase Mdm2 but also on Hsp70 and Hsp90 chaperones that interact with its DNA binding
M. Boysen, Roman Kityk, M. Mayer
semanticscholar   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Benzo[a]pyrene-induced changes in carboxylesterase, acetylcholinesterase and heat shock protein 70 of Lymantria dispar (Lepidoptera: Lymantriidae) from unpolluted and polluted forests [PDF]

Archives of Biological Sciences, 2019
Plant vegetation accumulates polycyclic aromatic hydrocarbons (PAHs) among which benzo[a]pyrene (B[a]P) is recognized as being very toxic, including cancerogenic. Lymantria dispar L. larvae are sensitive to changes in the environment, providing potential
Grčić Anja, Ilijin Larisa, Mrdaković Marija, Vlahović Milena, Filipović Aleksandra, Đurašević Siniša, Perić-Mataruga Vesna   +6 more
doaj   +1 more source