Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection [PDF]
International Journal of Molecular Sciences, 2021 Heat shock proteins (HSPs) are a large group of chaperones found in most eukaryotes and bacteria. They are responsible for the correct protein folding, protection of the cell against stressors, presenting immune and inflammatory cytokines; furthermore, they are important factors in regulating cell differentiation, survival and death.
Anna Lubkowska +3 more
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Cells, 2021 Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal system for protecting cells and the whole body from various types of stress.
Olga G. Zatsepina +2 more
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Heat Shock Protein 70 Deficient Mice Exhibit Reduced Psoriasis-like Skin Inflammation [PDF]
BiomedicinesBackground/Objectives: Psoriasis is a chronic, systemic, and multifactorial disease affecting approximately 1–2% of the Caucasian population. It is characterized by distinct histopathological features, including epidermal hyperplasia and infiltration of ...
Aikaterini Kalantidou +8 more
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SARS-CoV-2 Helicase (NSP13) Interacts with Mammalian Polyamine and HSP Partners in Promoting Viral Replication [PDF]
Current Issues in Molecular BiologyWe present a computational study that precedes the potential interactions between SARS-CoV-2 helicase (NSP13) and selected host proteins implicated in chaperone-assisted folding and polyamine metabolism.
Zingisa Sitobo +7 more
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Differential roles of HSP70 and HSP90 in Senecavirus A infection: IRES-dependent translational regulation and viral replication mechanisms [PDF]
VirulenceAs opportunistic intracellular pathogens, viruses rely on numerous sequential interactions between host and viral factors for their replication. Given the significance of molecular chaperones (heat shock protein 70 and heat shock protein 90) in mediating
Chen Li +5 more
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Heat shock proteins HSP27, HSP60, HSP70, and HSP90 [PDF]
Cancer, 2003 AbstractBACKGROUNDHeat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in neoplasia has been implicated in the regulation of apoptosis, and HSPs also can act by increasing immunity. In the current study, the authors attempted to clarify the significance of HSPs in
Thierry, Lebret +6 more
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HSP70: a promising target for laryngeal carcinoma radiaotherapy by inhibiting cleavage and degradation of nucleolin [PDF]
Journal of Experimental & Clinical Cancer Research, 2010 Previous studies have shown that heat shock proteins (HSPs) were upregulated in various types of tumors and were associated with histological grade, recurrence and metastasis of malignant tumors.
Xu Jing +7 more
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Genome-wide transcriptomic analysis reveals autophagy and HSP70-mediated mechanisms underlying thermal stress adaptation in Mytilus coruscus [PDF]
BMC GenomicsRising ocean temperatures driven by global warming pose a major threat to marine organisms. In this study, we examined physiological and molecular changes in the muscle, gill, foot, and mantle tissues of Mytilus coruscus under thermal stress ...
Chao Li +4 more
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Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
Life Science Alliance, 2022 Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.
Shingo Kose +5 more
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Non-lethal heat shock increased Hsp70 and immune protein transcripts but not Vibrio tolerance in the white-leg shrimp. [PDF]
PLoS ONE, 2013 Non-lethal heat shock boosts bacterial and viral disease tolerance in shrimp, possibly due to increases in endogenous heat shock protein 70 (Hsp70) and/or immune proteins.
Nguyen Hong Loc +5 more
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