Results 271 to 280 of about 170,313 (323)

Expression of HSP70 Heat-Shock Proteins under Oxidative Stress

Advances in Gerontology, 2020
The development of oxidative stress inevitably causes damage to cell proteins in need of timely refolding. The synthesis of the proteins of the heat-shock group is the most ancient and effective mechanism of cell protection. The life-long cellular adaptation to a huge number of cytotoxic factors, both of xenobiotic and natural origin, have provided ...
N. A. Kurashova, I. M. Madaeva, L. I. Kolesnikova   +2 more
openaire   +2 more sources

Heat shock protein (HSP70) expression in septic patients

Journal of Critical Care, 1997
This study investigates heat shock protein 70 (HSP70) expression by peripheral blood mononuclear cells (PBMCs) of septic patients admitted to an intensive care unit and examines the possibility of a correlation between HSP70 levels and plasma tumor necrosis factor alpha (TNF-alpha) concentrations. Additionally, we evaluated whether the HSP70 production
G, Delogu, L, Lo Bosco, M, Marandola, G, Famularo, L, Lenti, F, Ippoliti, L, Signore   +6 more
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cDNA of Canine Heat Shock Protein 70 (HSP70)

Veterinary Research Communications, 2004
Full-length canine HSP70 cDNA was sequenced and the expression of HSP70 mRNA was investigated. The full-length cDNA sequence of the HSP70 gene (2322 bp) contained a single long open reading frame (1920 bp) coding a protein of 640 amino acids. The amino acid sequence of the canine HSP70 gene shared about 90-95% sequence similarity with bovine, human and
R, Kano, K, Abe, A, Hasegawa
openaire   +2 more sources

Heat shock proteins HSP70 and GP96: structural insights

Cancer Immunology, Immunotherapy, 2005
Several heat shock proteins (HSPs) act as potent adjuvants for eliciting anti-tumor immunity. HSP-based tumor vaccine strategies have been highly successful in animal models and are undergoing testing in clinical trials. It is generally accepted that HSPs, functioning as chaperones for tumor antigens, elicit tumor-specific adaptive immune responses ...
John G, Facciponte, Xiang-Yang, Wang, Ian J, MacDonald, Jun-eui, Park, Hilal, Arnouk, Melissa J, Grimm, Ying, Li, Hyung, Kim, Masoud H, Manjili, Douglas P, Easton, John R, Subjeck   +10 more
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Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis

Glia, 1996
Although severe acidosis is an important mediator of brain infarction, recent evidence suggests that mild acidosis may protect ischemic cells. The HSP70 heat shock protein is induced by acidosis in cultured cells and in ischemic brain and protects cells against many types of injury.
P, Narasimhan, R A, Swanson, S M, Sagar, F R, Sharp   +3 more
openaire   +2 more sources

Heat Shock Protein HSP70 in Oxidative Stress in Apnea Patients

Bulletin of Experimental Biology and Medicine, 2020
We studied the level of heat shock protein HSP70 under conditions of oxidative stress in 47 patients with apnea. The control group included 13 healthy subjects without verified apnea. Blood serum, plasma, and erythrocyte hemolysate were used to determine LPO and anti-oxidant protection components by spectrophotometrical and spectrofluorometrical ...
I M, Madaeva, N A, Kurashova, N V, Semenova, E B, Ukhinov, S I, Kolesnikov, L I, Kolesnikova   +5 more
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Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer.

Current Drug Targets, 2017
BACKGROUND Heat Shock Proteins (HSPs) constitute a group of proteins that play a crucial role in the process of protein folding. HSPs are also known to modulate a number of key apoptotic factors.
Jasleen Saini, P. Sharma
semanticscholar   +1 more source

Heat shock proteins HSP27 and HSP70 in unilateral obstructed kidneys

Pediatric Nephrology, 2003
Unilateral ureteropelvic junction obstruction (UPJO), a condition involving injury to the kidney, leads to vasoconstriction, macrophage infiltration, oxidative stress, and tubulointerstitial fibrosis. In the present study we analyzed in 22 children, the impact of UPJO on expression of HSP27 and HSP70 and related the changes to renal function and ...
Patricia, Vallés, Facundo, Jorro, Liliana, Carrizo, Walter, Manucha, Julio, Oliva, F Darío, Cuello-Carrión, Daniel R, Ciocca   +6 more
openaire   +2 more sources

HSP70-2 heat-shock protein of mouse spermatogenic cells

The Journal of Experimental Zoology, 1998
The HSP70 heat-shock proteins are molecular chaperones that assist other proteins in folding, transport, and assembly into complexes. The genes for these proteins are either constitutively expressed (Hsc70, Grp78), or their expression is induced by heat shock and other stresses (Hsp70-1, Hsp70-3).
openaire   +3 more sources