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Immunostimulatory properties of the Leishmania infantum heat shock proteins HSP70 and HSP83
Molecular Immunology, 1999Emerging evidence indicates that the heat shock proteins (HSPs), a set of highly evolutionary conserved proteins, are playing essential roles in both normal processes of the immune system and specific immune responses. In a previous work, we demonstrated that the Leishmania infantum HSP70 possesses remarkable immunostimulatory properties.
Ana Isabel Rico +2 more
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Heat shock protein (HSP70) expression in septic patients
Journal of Critical Care, 1997This study investigates heat shock protein 70 (HSP70) expression by peripheral blood mononuclear cells (PBMCs) of septic patients admitted to an intensive care unit and examines the possibility of a correlation between HSP70 levels and plasma tumor necrosis factor alpha (TNF-alpha) concentrations. Additionally, we evaluated whether the HSP70 production
G, Delogu +6 more
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Heat Shock Protein HSP70 in Oxidative Stress in Apnea Patients
Bulletin of Experimental Biology and Medicine, 2020We studied the level of heat shock protein HSP70 under conditions of oxidative stress in 47 patients with apnea. The control group included 13 healthy subjects without verified apnea. Blood serum, plasma, and erythrocyte hemolysate were used to determine LPO and anti-oxidant protection components by spectrophotometrical and spectrofluorometrical ...
I M, Madaeva +5 more
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cDNA of Canine Heat Shock Protein 70 (HSP70)
Veterinary Research Communications, 2004Full-length canine HSP70 cDNA was sequenced and the expression of HSP70 mRNA was investigated. The full-length cDNA sequence of the HSP70 gene (2322 bp) contained a single long open reading frame (1920 bp) coding a protein of 640 amino acids. The amino acid sequence of the canine HSP70 gene shared about 90-95% sequence similarity with bovine, human and
R, Kano, K, Abe, A, Hasegawa
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Heat shock proteins HSP70 and GP96: structural insights
Cancer Immunology, Immunotherapy, 2005Several heat shock proteins (HSPs) act as potent adjuvants for eliciting anti-tumor immunity. HSP-based tumor vaccine strategies have been highly successful in animal models and are undergoing testing in clinical trials. It is generally accepted that HSPs, functioning as chaperones for tumor antigens, elicit tumor-specific adaptive immune responses ...
John G, Facciponte +10 more
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Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis
Glia, 1996Although severe acidosis is an important mediator of brain infarction, recent evidence suggests that mild acidosis may protect ischemic cells. The HSP70 heat shock protein is induced by acidosis in cultured cells and in ischemic brain and protects cells against many types of injury.
P, Narasimhan +3 more
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Heat shock proteins HSP27 and HSP70 in unilateral obstructed kidneys
Pediatric Nephrology, 2003Unilateral ureteropelvic junction obstruction (UPJO), a condition involving injury to the kidney, leads to vasoconstriction, macrophage infiltration, oxidative stress, and tubulointerstitial fibrosis. In the present study we analyzed in 22 children, the impact of UPJO on expression of HSP27 and HSP70 and related the changes to renal function and ...
Patricia, Vallés +6 more
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