Results 61 to 70 of about 170,313 (323)

Heat Shock Protein (Hsp) 40 Mutants Inhibit Hsp70 in Mammalian Cells [PDF]

Journal of Biological Chemistry, 1999
Heat shock protein (Hsp) 70 and Hsp40 expressed in mammalian cells had been previously shown to cooperate in accelerating the reactivation of heat-denatured firefly luciferase (Michels, A. A., Kanon, B., Konings, A. W. T., Ohtsuka, K., Bensaude, O., and Kampinga, H. H. (1997) J. Biol. Chem. 272, 33283-33289).
Michels, AA, Kanon, B, Bensaude, O, Kampinga, HH   +3 more
openaire   +3 more sources

Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity. [PDF]

PLoS ONE, 2015
Tumor-derived heat shock protein70-peptide complexes (HSP70.PC-Tu) have shown great promise in tumor immunotherapy due to numerous advantages. However, large-scale phase III clinical trials showed that the limited immunogenicity remained to be enhanced ...
Yunfei Zhang, Yong Zhang, Jun Chen, Yunyan Liu, Wen Luo   +4 more
doaj   +1 more source

Functions of J-domain proteins in mitochondrial protein biogenesis. [PDF]

Protein Sci
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Tiku V, Bossenz G, Kirstein J, Becker T.
europepmc   +2 more sources

Responses of heat shock protein 70 and caspase-3/7 to dietary selenomethionine in juvenile white sturgeon. [PDF]

, 2016
An 8-week feeding trial was conducted to investigate the responses of juvenile white sturgeon (Acipenser transmontanus) to elevated dietary selenium (Se) based on the determination of the RNA/DNA ratio in muscle, heat shock protein 70 (Hsp70), and ...
Deng, Dong-Fang, Hung, Silas SO, Lee, Seunghyung, Wang, Weifang   +3 more
core   +1 more source

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

International Journal of Molecular Sciences, 2018
Among diseases whose cure is still far from being discovered, Alzheimer’s disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including ...
C. Campanella, A. Pace, Celeste Caruso Bavisotto, Paola Marzullo, A. Marino Gammazza, S. Buscemi, A. Palumbo Piccionello   +6 more
semanticscholar   +1 more source

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Advanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan, Kenny Man, Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj   +9 more
wiley   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Monitoring the Induction of Heat Shock Factor 1/Heat Shock Protein 70 Expression following 17-Allylamino-Demethoxygeldanamycin Treatment by Positron Emission Tomography and Optical Reporter Gene Imaging

Molecular Imaging, 2012
The cell response to proteotoxic cell stresses is mediated primarily through activation of heat shock factor 1 (HSF1). This transcription factor plays a major role in the regulation of the heat shock proteins (HSPs), including HSP70.
Mikhail Doubrovin, Jian T. Che, Inna Serganova, Ekaterina Moroz, David B. Solit, Lyudmila Ageyeva, Tatiana Kochetkova, Nagavarakishore Pillarsetti, Ronald Finn, Neal Rosen, Ronald G. Blasberg   +10 more
doaj   +1 more source

Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases

International Journal of Molecular Sciences
The heat shock response is an evolutionarily conserved mechanism that protects cells or organisms from the harmful effects of various stressors such as heat, chemicals toxins, UV radiation, and oxidizing agents.
Manish Kumar Singh, Yoonhwa Shin, Songhyun Ju, Sunhee Han, W. Choe, Kyung-Sik Yoon, Sung Soo Kim, I. Kang   +7 more
semanticscholar   +1 more source