Results 61 to 70 of about 50,507 (259)

In-vivo Thermal Stress Induces Melatonin Receptors and Heat Shock Proteins Expression in the Spleen of Mice in a Time and Temperature Dependent Manner [PDF]

Journal of Stress Physiology & Biochemistry, 2023
Heat shock proteins (Hsps) responses against stress conditions. Melatonin completes its stress relieving activities via its MT1 and MT2 receptors. The present study delineates the expression pattern of Hsp70/Hsc70 and MT1/MT2 receptor proteins along with
Samik Acharjee, Shiv Shankar Singh
doaj  

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source

Exploring variations in heat shock protein 70 expression among vulnerable populations across urban and rural areas in Klang Valley [PDF]

E3S Web of Conferences
As global temperatures rise due to climate change, the occurrence and intensity of heat waves are anticipated to increase. Despite this anticipation, there remains a gap in comprehending the underlying defense mechanisms against heat stress, particularly
Muhamad Siti Nurfahirah, How Vivien, Akim Abdah Md, Lim Fang Lee, Shabri Nur Shabrina Azreen Mohd   +4 more
doaj   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Differential roles of HSP70 and HSP90 in Senecavirus A infection: IRES-dependent translational regulation and viral replication mechanisms

Virulence
As opportunistic intracellular pathogens, viruses rely on numerous sequential interactions between host and viral factors for their replication. Given the significance of molecular chaperones (heat shock protein 70 and heat shock protein 90) in mediating
Chen Li, Yingru Ma, Chang Liu, Shaojian Xu, Jianli Shi, Jun Li   +5 more
doaj   +1 more source

Artificial Chlorella Biohybrids for Alleviation of Cartilage Degeneration in Osteoarthritis

Exploration, EarlyView.
Artificial Chlorella biohybrids (Ch@P) alleviate cartilage degeneration and protect against OA progression by activating mitophagy and reprogramming glucose metabolism in chondrocytes, as well as inducing articular thermal stimulation under near infrared irradiation.
Yongyun Chang, Keyu Kong, Minghao Jin, Shasha Liu, Yangzi Yang, Yingchun Zhu, Hua Qiao, Wenxuan Fan, Xinru Wu, Jingwei Zhang, Yansong Qi, Yongsheng Xu, Xiang Feng, Pingcuo Nima, Piting Ji, Tariel Mamuladze, Andrei A. Korytkin, Huiwu Li, Jingke Fu, Zanjing Zhai   +19 more
wiley   +1 more source

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

Molecular Metabolism, 2019
Objective: Heat Shock Proteins (HSPs) maintain cellular homeostasis under stress. HSP70 represents a major stress-inducible family member and has been identified as a druggable target in inherited cholesterol-sphingolipid storage diseases.
Burcin Gungor, Lauri Vanharanta, Maarit Hölttä-Vuori, Juho Pirhonen, Nikolaj H.T. Petersen, Silvia Gramolelli, Päivi M. Ojala, Thomas Kirkegaard, Elina Ikonen   +8 more
doaj   +1 more source

Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology

Exploration, EarlyView.
Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen, Wenzhe Yi, Rongzhang Li, Shuangshuang Hu, Xindi Qian, Dan Yan, Qian Zou, Guanru Wang, Yaping Li   +8 more
wiley   +1 more source

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

eLife, 2016
Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in
Xu Zheng, Joanna Krakowiak, Nikit Patel, Ali Beyzavi, Jideofor Ezike, Ahmad S Khalil, David Pincus   +6 more
doaj   +1 more source