Results 111 to 120 of about 138,190 (352)
Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads [PDF]
, 2017 Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range.
Agard, Da +10 more
core +1 more source
Retracted: Impact of HSP90α, CEA, NSE, SCC, and CYFRA21‐1 on Lung Cancer Patients [PDF]
, 2023 Journal of Healthcare Engineering
openalex +1 more source
Macrocyclic Inhibitors of Hsp90 [PDF]
Current Topics in Medicinal Chemistry, 2010 Heat shock proteins (HSP) are a family of highly conserved proteins, whose expression increases in response to stresses that may threaten cell survival. Over the past decade, heat shock protein 90 (Hsp90) has emerged as a potential therapeutic target for cancer as it plays a vital role in normal cell maturation and acts as a molecular chaperone for ...
Johnson, V +4 more
openaire +3 more sources
Advanced Intelligent Discovery, EarlyView.Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz +2 more
wiley +1 more source
The clickable activity-based probe of anti-apoptotic calenduloside E
Pharmaceutical Biology, 2019 Context: Calenduloside E (CE), one of the primary natural products found in Aralia elata (Miq.) Seem. (Araliaceae), possesses prominent anti-apoptotic potential.
Yu Tian +8 more
doaj +1 more source
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
Nature Communications, 2017 Cachexia, characterized by muscle wasting, is a major contributor to cancer-related mortality. However, the key cachexins that mediate cancer-induced muscle wasting remain elusive.
Guohua Zhang +11 more
semanticscholar +1 more source
Supplementary Figure 2 from A Purine Scaffold HSP90 Inhibitor BIIB021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K13-Induced NF-κB [PDF]
, 2023 Gopalakrishnan Ramakrishnan +2 more
openalex +1 more source
Hsp90: Chaperoning signal transduction [PDF]
Journal of Cellular Physiology, 2001 AbstractHsp90 is an ATP dependent molecular chaperone involved in the folding and activation of an unknown number of substrate proteins. These substrate proteins include protein kinases and transcription factors. Consistent with this task, Hsp90 is an essential protein in all eucaryotes. The interaction of Hsp90 with its substrate proteins involves the
K, Richter, J, Buchner
openaire +2 more sources
Annals of Neurology, EarlyView.Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang +10 more
wiley +1 more source
Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone. [PDF]
PLoS ONE, 2016 The Hsp90 chaperone activity is tightly regulated by interaction with many co-chaperones. Since CacyBP/SIP shares some sequence homology with a known Hsp90 co-chaperone, Sgt1, in this work we performed a set of experiments in order to verify whether ...
Agnieszka Góral +6 more
doaj +1 more source