Results 141 to 150 of about 138,190 (352)
Journal of Inflammation Research, 2023 Paihe Deng, Huimin Hu Clinical Laboratory Medicine Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210011, People’s Republic of ChinaCorrespondence: Huimin Hu, Clinical Laboratory Medicine Center, The Second ...
Deng P, Hu H
doaj
Heat shock protein 90 mediates the protective effects of vericiguat on myocardial ischemia/reperfusion injury by inhibiting toll-like receptor 4 and c-Jun N-terminal kinases [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): This study aimed to investigate whether vericiguat exerts a protective effect against myocardial ischemia-reperfusion injury (MIRI) by inhibiting toll-like receptor 4 (TLR4) and c-Jun N-terminal kinases (JNK) activation and whether heat ...
Sijie Pan +7 more
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Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer [PDF]
, 2018 In this study, we report how the cholera toxin (CT) A subunit (CTA), the enzyme moiety responsible for signaling alteration in host cells, enters the exosomal pathway, secretes extracellularly, transmits itself to a cell population.
Boussadia, Zaira +11 more
core +1 more source
Inhibitors of HSP90 in melanoma
Apoptosis, 2019 HSP90 (heat shock protein 90) is an ATP-dependent molecular chaperone involved in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed in cancer, including melanoma.
Aleksandra Mielczarek-Lewandowska +2 more
semanticscholar +1 more source
BioMolecular Concepts, 2012 AbstractMolecular chaperones are key components in the maintenance of cellular homeostasis and survival, not only during stress but also under optimal growth conditions. Among the ATP-dependent chaperones, heat shock proteins (Hsp90) proteins play a special role.
Stankiewicz Marta, Mayer Matthias P.
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iNew Medicine, EarlyView.ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi +14 more
wiley +1 more source
Microbial CellVarious stress conditions, such as heat stress (HS) and oxidative stress, can cause biomolecular condensates represented by stress granules (SGs) via liquid-liquid phase separation.
Naofumi Tomimoto +2 more
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HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
Nature Communications, 2017 T-cell-based immunotherapies are promising treatments for cancer patients. Although durable responses can be achieved in some patients, many patients fail to respond to these therapies, underscoring the need for improvement with combination therapies ...
Rina M Mbofung +27 more
semanticscholar +1 more source
Pathology & Oncology Research, 2013 With increasing understanding of the molecular basis of carcinogenesis, its progression and metastasis, the cancer therapy has shifted from empirical approaches to targeting specific molecules that regulate the complex network of signalling pathways for cell survival and proliferation.
J M, Patki, S S, Pawar
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