Results 151 to 160 of about 138,190 (352)

Achieving superior therapeutic effects on methicillin‐resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer

Interdisciplinary Medicine, EarlyView.
The sulfonated zwitterionic photosensitizer (PYSO3) is synthesized by reacting maleic anhydride derivatives with 4‐aminopyridine to form PY, followed by sulfonation with 1,4‐butane sultone. It exhibits both photothermal and photodynamic properties, enabling effective eradication of MRSA and biofilms, as well as promoting wound healing in mice ...
Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun   +10 more
wiley   +1 more source

RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS

Медицинская иммунология, 2014
.  A  study  was  performed  aiming  to  investigate  interactions  between  TNFα  receptor  (TNF1) superfamily and heat shock protein Hsp90, using a Jurkat tumor cell line.
N. V. Ryazantseva, E. V. Kaygorodova, M. V. Belkina, A. N. Maroshkina, O. E. Chechina, A. P. Zima, V. V. Novitskii   +6 more
doaj   +1 more source

In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma. [PDF]

, 2016
The long-term overall survival of Ewing sarcoma (EWS) patients remains poor; less than 30% of patients with metastatic or recurrent disease survive despite aggressive combinations of chemotherapy, radiation and surgery.
Alturkmani, Hani, Baltezor, Michael, Butte, Atul J, Chen, Bin, Flynn, Colleen A, Godwin, Andrew K, Hyter, Stephen, Ma, Yan, Neville, Kathleen A, Pessetto, Ziyan Y, Rosenthal, Howard G, Weir, Scott J   +11 more
core   +3 more sources

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

Scientific Reports, 2017
Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be ...
Manuel Schuster, Leonie Schnell, P. Feigl, Carina Birkhofer, Katharina B. Mohr, Maurice Roeder, Stefan Carle, Simon Langer, Franziska Tippel, J. Buchner, G. Fischer, F. Hausch, M. Frick, Carsten Schwan, K. Aktories, C. Schiene‐Fischer, H. Barth   +16 more
semanticscholar   +1 more source

Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu, Yingzhang Cai, Conghui Yu, Ning Lin, Miaolian Chen, Linli Wang   +5 more
wiley   +1 more source

Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 [PDF]

, 2017
We thank Zhen-Yuan Lin for help in the preparation of the AP-MS samples, and Cathy Collins for technical assistance. MDL is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), LEC is supported by a Canada Research Chair in ...
Bohovych, Iryna, Cowen, Leah E., Gingras, Anne-Claude, Khalimonchuk, Oleh, Lambert, Jean-Philippe, Leach, Michelle, Wong, Erin O Y, Xie, Jinglin L   +7 more
core   +4 more sources

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Evolvability of Chaperonin Substrate Proteins [PDF]

, 2009
Molecular chaperones ensure that their substrate proteins reach the functional native state, and prevent their aggregation. Recently, an additional function was proposed for molecular chaperones: they serve as buffers (_capacitors_) for evolution by ...
Emanuele Raineri, Luis Serrano, Paolo Ribeca, Tobias Maier   +3 more
core   +1 more source

A CRY-BIC negative-feedback circuitry regulating blue light sensitivity of Arabidopsis. [PDF]

, 2017
Cryptochromes are blue light receptors that regulate various light responses in plants. Arabidopsis cryptochrome 1 (CRY1) and cryptochrome 2 (CRY2) mediate blue light inhibition of hypocotyl elongation and long-day (LD) promotion of floral initiation. It
Gu, Lianfeng, Han, Yun-Jeong, He, Wenjin, Kim, Jeong-Il, Lin, Chentao, Liu, Bin, Liu, Bobin, Liu, Qing, Matsui, Minami, Oka, Yoshito, Su, Jun, Wang, Jian, Wang, Qin, Wang, Xu, Yang, Zhaohe, Zuo, Zecheng   +15 more
core   +2 more sources

Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism

Nature, 2021
R. Wang, C. Noddings, Elaine Kirschke, A. Myasnikov, Jill L. Johnson, D. Agard   +5 more
semanticscholar   +1 more source