Results 151 to 160 of about 108,942 (214)

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway. [PDF]

Int J Mol Med
Zhu Y, Wang X, Lin J, Wang X, Zheng K, Ren Z, Xiao J, Wang Y.   +7 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, Volume 15, Issue 4, April 2026.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite. [PDF]

Sci Rep
Campenet S, Lamarre M, Durand J, Perez V, Peixoto P, Delage-Mourroux R, Guittaut M, Baguet A, Despouy G.   +8 more
europepmc   +1 more source

Streamlined One‐Pot Synthesis of Fused Pyrroles: A Three‐Component Approach

ChemistryOpen, Volume 15, Issue 4, April 2026.
New modified pyrrole derivatives, namely tetrahydroindol‐4‐ones and pyrrolo[2,3‐d]pyrimidines, functionalized at position 3, were synthesized through a one‐pot multicomponent condensation. Stabilized dimedone enaminones derived from α‐amino acids and their esters (or 6‐amino‐1,3‐dimethyluracil), arylglyoxals, and methylene‐active compounds ...
Kateryna I. Marchenko, Vladislava I. Grinko, Roman M. Gutzul, Oleksandr S. Kharchenko, Henning J. Jessen, Nadiia N. Kolos   +5 more
wiley   +1 more source

[Expression of Concern] Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling. [PDF]

Mol Med Rep
Yin L, Chen X, Ji H, Gao S.
europepmc   +1 more source

Functions of J‐domain proteins in mitochondrial protein biogenesis

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Vitasta Tiku, Georg Bossenz, Janine Kirstein, Thomas Becker   +3 more
wiley   +1 more source

Heat shock proteins (Hsp70 and Hsp90) in neurodegeneration: pathogenic roles and therapeutic potential. [PDF]

Front Aging Neurosci
Ben Khalaf N.
europepmc   +1 more source

ApoJ regulates endothelial lipase activity and stability

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Endothelial lipase (EL) is a key regulator of high‐density lipoprotein (HDL) metabolism. Many aspects of EL function remain incompletely understood due to challenges in purifying active EL. This study identifies apolipoprotein J (ApoJ) as a novel chaperone for EL, crucial for its solubility and activity.
Uriel L. Jean‐Baptiste, Simcha R. Singh, Ming J. Wu, Kellen Christina da Cruz Rodriguez, Young‐Bum Kim, Saskia B. Neher   +5 more
wiley   +1 more source

Embracing diversity: Post-translational modifications, the chaperone code, and the emergence of new chaperone entities. [PDF]

Cell Stress Chaperones
Digwal CS, Wang S, Chiosis G.
europepmc   +1 more source

HSP90 proteins in the scenario of tumor complexity [PDF]

, 2017
Rasola, Andrea
core   +1 more source