Results 221 to 230 of about 138,190 (352)

The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE

, 2012
Lucia Lisi, Susan O. McGuire, Anthony Sharp, Gabriela Chiosis, Pierluigi Navarra, Douglas L. Feinstein, Cinzia Dello Russo   +6 more
openalex   +2 more sources

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

STAT3 interacts directly with Hsp90 [PDF]

, 2012
Earl Prinsloo, Adam H. Kramer, Adrienne L. Edkins, Gregory L. Blatch   +3 more
openalex   +1 more source

BiGraph‐DTA: Predicting drug–target interactions of hepatoprotective agents with graph convolutional networks

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Predicting drug–target affinity (DTA) is critical for discovering and developing hepatoprotective agents that can prevent and treat liver diseases. In this study, we propose BiGraph‐DTA, a new predictive model for identifying DTA score prediction for hepatoprotective compounds by combining graph convolutional networks and bidirectional long ...
Arief Sartono, Bambang Riyanto Trilaksono, Sophi Damayanti, Anto Satriyo Nugroho, Firdayani Firdayani   +4 more
wiley   +1 more source

Targeting Hsp90 in Cancer for 25 Years: Failure of Previous Clinical Trials and New Hope for Future Therapeutics. [PDF]

Cells
Chen M, Chang C, Miao KL, Woodley DT, Li W.   +4 more
europepmc   +1 more source

Phase Ib study of HSP90 inhibitor, onalespib (AT13387), in combination with paclitaxel in patients with advanced triple-negative breast cancer

, 2023
Nicole Williams, Dionisia Quiroga, Courtney Johnson, Adam Brufsky, Mara Chambers, Saveri Bhattacharya, Maria Patterson, Sagar Sardesai, Daniel G. Stover, Maryam B. Lustberg, Anne M. Noonan, Mathew Cherian, Darlene M. Bystry, Kasey Hill, Min Chen, Mitch A. Phelps, Michael R. Grever, Julie Stephens, Bhuvaneswari Ramaswamy, William E. Carson, Robert Wesolowski   +20 more
openalex   +1 more source

Integrative machine learning approach for identifying genes associated with quantitative traits: A soybean (Glycine max) yield case study

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract To improve the identification of minor‐effect molecular markers and genes associated with quantitative traits, addressing inefficiencies in traditional molecular marker mining and the limited impact of these markers in practical breeding, we analyzed over 15,000 soybean (Glycine max) genotypes across nine maturity groups using an AI‐driven ...
Wei Zhou, Haoyong Ouyang, Zhengxiao Yan, Jiayi Song, Yichan Li, Zhou Tang, Chang Zhao   +6 more
wiley   +1 more source

The dihydropyridine LA1011 modulates multiple Hsp90-co-chaperone interactions relevant to Alzheimer's disease. [PDF]

Cell Stress Chaperones
Jeanne X, Oberoi J, Roe MS, Baud M, Spencer J, Torok Z, Vigh L, Prodromou C.   +7 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, Volume 16, Issue 2, Page 382-396, February 2026.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Differential roles of HSP70 and HSP90 in Senecavirus A infection: IRES-dependent translational regulation and viral replication mechanisms. [PDF]

Virulence
Li C, Ma Y, Liu C, Xu S, Shi J, Li J.
europepmc   +1 more source