Results 41 to 50 of about 138,190 (352)
Regulated Transport into the Nucleus of Herpesviridae DNA Replication Core Proteins
Viruses, 2013 The Herpesvirdae family comprises several major human pathogens belonging to three distinct subfamilies. Their double stranded DNA genome is replicated in the nuclei of infected cells by a number of host and viral products.
Alessandro Ripalti +6 more
doaj +1 more source
P53 in lung vascular barrier dysfunction
Vascular Biology, 2020 Endothelial barrier dysfunction is the hallmark of inflammatory lung disease, including Acute Lung Injury and Acute Respiratory Distress Syndrome. The purpose of the present editorial is to emphasize on recent advances in the corresponding field, as it ...
Nektarios Barabutis
doaj +1 more source
HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation
Cells, 2020 Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that controls the function and stability of a wide range of cellular client proteins.
Abir Chakraborty +2 more
doaj +1 more source
A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a [PDF]
, 2011 Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma.
Adi Mehta +55 more
core +2 more sources
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB
Journal of Investigative Surgery, 2022 Objective We previously showed that HSP90 is involved in postconditioning cardioprotection by inhibiting complement C5a. Here, we investigated whether HSP90-mediated C5a/NF-κB inhibition is responsible for the cardioprotection conferred by liraglutide ...
Shi-Tao He +6 more
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Ras hyperactivation versus overexpression : Lessons from Ras dynamics in Candida albicans [PDF]
, 2018 We thank Prof. Neta Dean for the CIp10ADH1-Cherry plasmid and Prof. Aaron Mitchell for the BWP17 strain. We gratefully acknowledge Prof. Sudipta Maiti, TIFR, Mumbai, India for providing the data acquisition software.
Haokip, Dominic T +10 more
core +3 more sources
Identification of HSP90 inhibitors as a novel class of senolytics
Nature Communications, 2017 Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased senescent cell burden in various tissues is a major contributor to aging and age-related diseases.
Heike Fuhrmann-Stroissnigg +19 more
semanticscholar +1 more source
Aneuploidy and proteotoxic stress in cancer [PDF]
, 2015 Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between ...
Donnelly, N., Storchova, Z.
core +2 more sources
Trends in Biochemical Sciences, 2010 The telomere environment requires an efficient means to assemble and disassemble a multitude of structures to operate correctly and to help achieve cellular homeostasis. Telomeres are challenged by a common binding specificity displayed by many of the protein components for telomeric DNA, which could result in competitive DNA interactions, and by a ...
Diane C, DeZwaan, Brian C, Freeman
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Effects of a novel HSP90 inhibitor on estrogen receptor α signaling pathways in breast cancer cells
Успехи молекулярной онкологииIntroduction. Heat shock proteins (HSP), also known as molecular chaperones, are a large family of proteins that play crucial roles in histogenesis, homeostasis, and the folding and functional regulation of numerous client proteins.
A. M. Scherbakov +7 more
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