Results 51 to 60 of about 138,190 (352)
Hsp-90 and the biology of nematodes [PDF]
, 2009 BACKGROUND: Hsp-90 from the free-living nematode Caenorhabditis elegans is unique in that it fails to bind to the specific Hsp-90 inhibitor, geldanamycin (GA).
Devaney, E. +4 more
core +3 more sources
Exploration of MedicineAim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome.
Jayasree Santhanakrishnan +2 more
doaj +1 more source
Microbiology Spectrum, 2023 Thermotolerance is a remarkable virulence attribute of Aspergillus fumigatus, but the consequences of heat shock (HS) to the cell membrane of this fungus are unknown, although this structure is one of the first to detect changes in ambient temperature ...
João Henrique Tadini Marilhano Fabri +6 more
doaj +1 more source
Regulatory Mechanisms of Hsp90 [PDF]
Biochemistry & Molecular Biology Journal, 2017 The ability of Hsp90 to activate a disparate clientele implicates this chaperone in diverse biological processes. To accommodate such varied roles, Hsp90 requires a variety of regulatory mechanisms that are coordinated in order to modulate its activity appropriately. Amongst these, the master-regulator heat shock factor 1 (HSF1) is critically important
openaire +3 more sources
Hsp90 canalizes developmental perturbation [PDF]
Journal of Experimental Botany, 2007 Stochastic processes are intrinsic phenomena that perturb developmental processes. However, the canalization process restricts the magnitude of perturbation and hence the magnitude of morphological variation during development. Heat-shock protein 90 (Hsp90) chaperones are a class of proteins stabilizing a network of 'client' proteins that are involved ...
Despina, Samakovli +3 more
openaire +2 more sources
Journal of Biological Research - Thessaloniki, 2022 The present study aimed to explore the pathway through which Heat Shock Protein 70 (HSP70) is involved in inflammation and sepsis and the possible interaction with glutamine, an essential nutrient during sepsis. We also evaluated the possible interaction
Ioanna Plati +5 more
doaj +1 more source
Conformational dynamics of a single protein monitored for 24 hours at video rate [PDF]
, 2018 We use plasmon rulers to follow the conformational dynamics of a single protein for up to 24 h at a video rate. The plasmon ruler consists of two gold nanospheres connected by a single protein linker.
Ahijado-Guzmán, Rubén +10 more
core +3 more sources
Open Medicine, 2021 Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury ...
Tu Rong-Hui +7 more
doaj +1 more source
Silence of STAT3 Enhances SNX-2112-induced Apoptosis of Esophageal Cancer Stem Cells
Zhongliu Fangzhi Yanjiu, 2019 Objective To investigate the effect of STAT3 silence on SNX-2112-induced apoptosis of esophageal cancer stem cells. Methods shSTAT3 lentiviral vector was designed and constructed. Esophageal cancer stem cells were transfected with shSTAT3 vector and then
XU Dandan, CHEN Suhong, WANG Ying
doaj +1 more source
Hydroxychloroquine induces long QT syndrome by blocking hERG channel
Frigid Zone Medicine, 2023 In March 2022, more than 600 million cases of Corona Virus Disease 2019 (COVID-19) and about 6 million deaths have been reported worldwide. Unfortunately, while effective antiviral therapy has not yet been available, chloroquine (CQ)/hydroxychloroquine ...
Zhao Xin +10 more
doaj +1 more source