Results 91 to 100 of about 3,381,955 (240)

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis [PDF]

, 2014
The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling.
Kasioulis, Ioannis, Jackson, Ian J., Botting, C. H., Botting, Catherine H., Kasioulis, I., Syred, H. M., Seawright, Anne, Fuszard, Matthew Alexander, Shirran, Sally, Van Heyningen, V., Tate, Peri, Finch, Andrew, Tate, P., Jackson, I. J., Adams, I. R., Syred, Heather M., Finch, A., Yeyati, P. L., Shaw, J., Shirran, S., Fuszard, M., Adams, Ian R., Shaw, Joseph, Seawright, A., Yeyati, Patricia L., van Heyningen, Veronica   +25 more
core   +1 more source

Interactions between extracellular Hsp72 and blood cells [PDF]

, 2010
Not to be added to EThOSIn recent years, compelling evidence has accumulated suggesting heat shock proteins (HSPs) which are generally believed to be localised and functioning mainly within eukaryotic cells as cyto-protective molecular chaperones, are ...
Williams, Helen
core   +2 more sources

A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.

PLoS ONE, 2012
Vascular endothelial growth factor A (VEGF-A) binds to the VEGFR2 receptor tyrosine kinase, regulating endothelial function, vascular physiology and angiogenesis.
Alexander F Bruns, Nadira Yuldasheva, Antony M Latham, Leyuan Bao, Caroline Pellet-Many, Paul Frankel, Sam L Stephen, Gareth J Howell, Stephen B Wheatcroft, Mark T Kearney, Ian C Zachary, Sreenivasan Ponnambalam   +11 more
doaj   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

Journal of Hematology & Oncology, 2018
Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins.
Ting Li, Hu-Lin Jiang, Yun-Guang Tong, Jin-Jian Lu   +3 more
doaj   +1 more source

Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu, I. A. Anjola, L. O. Fasasi, D. P. Fadipe, A. T. Afuye, F. O. Fasanya, O. E. Oke   +6 more
wiley   +1 more source

Therapeutic Drugs and Natural Products: The Effect of Suppressing Heat Shock Proteins (Hsp) in Brain Tumors

, 2022
Brain tumors are common in the population, and approximately 17,000 new patients are diagnosed every year. Although there are advancements in conventional treatment, including surgery, radiotherapy and chemotherapy, they have limited effectiveness for ...
Onay-Ucar, Evren, Mertoglu, Elif, Kiyga, Ezgi, Sengelen, Aslihan   +3 more
core   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Heat shock protein 90 chaperone activity is required for hepatitis A virus replication

Journal of Virology
HSP90 heat shock chaperones are essential for maintaining cellular proteostasis, as well as the ATP-dependent folding and functional maturation of many viral proteins. As a result, inhibitors of HSP90 have broad antiviral activity, disrupting replication
You Li, Xin Zheng, Ling Xie, Maryna Kapustina, Takayoshi Shirasaki, Bryan Yonish, Xian Chen, Asuka Hirai-Yuki, Noriyo Nagata, Ryosuke Suzuki, Masanori Isogawa, Matthew R. Vogt, Masamichi Muramatsu, Stanley M. Lemon   +13 more
doaj   +1 more source