Results 81 to 90 of about 59,092 (215)
Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90
Biochemical Society Transactions, 2017 The ability to permit gene expression is managed by a set of relatively well known regulatory mechanisms. Nonetheless, this property can also be acquired during a life span as a consequence of environmental stimuli. Interestingly, some acquired information can be passed to the next generation of individuals without modifying gene information, but ...
Mazaira, Gisela Ileana +4 more
openaire +3 more sources
Rethinking the role of HIF in hepatocellular carcinoma
The FEBS Journal, EarlyView.Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth +2 more
wiley +1 more source
The FEBS Journal, EarlyView.In this issue, Elmaleh et al. demonstrate that the E425K mutation in DNAJC7, associated with amyotrophic lateral sclerosis, selectively abolishes one of a co‐chaperone's dual functions. High‐resolution NMR confirmed that the mutation leaves the protein's structure intact while paralyzing its communication with the Hsp70 machinery.
Tsung‐Sheng Chiang +2 more
wiley +1 more source
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity [PDF]
, 2019 The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is ...
Backe, Sarah J +11 more
core +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Journal of Fish Biology, EarlyView.Abstract Climate‐driven aquatic heatwaves pose an increasing threat to fish populations by inducing prolonged thermal stress. However, the resilience of teleosts to chronic heat exposure and their capacity for recovery remains poorly understood. This study investigated the effects of chronic high‐temperature exposure on juvenile zebrafish (Danio rerio).
Monique Adzijovski +3 more
wiley +1 more source
A dajkafehérjék az öregedési folyamatokban = Molecular chaperones in the ageing process [PDF]
, 2008 A stresszválasz fontos szerepet játszik az öregedésben, és terápiás célpont a korfüggő betegségek kezelésében. Pályázatunkban kimutattuk, hogy (1) az öregedés kóroki tényezőjeként ismert oxidatív stressz osztódó sejtekben nem vezet fehérje denaturációhoz
Amere Subbarao, Sreedhar +3 more
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