Results 131 to 140 of about 59,353 (250)

Rethinking the role of HIF in hepatocellular carcinoma

The FEBS Journal, EarlyView.
Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth, Michael Batie, Sonia Rocha   +2 more
wiley   +1 more source

The role of Aha1 in cancer and neurodegeneration

Frontiers in Molecular Neuroscience
The 90 kDa Heat shock protein (Hsp90) is a family of ubiquitously expressed molecular chaperones responsible for the stabilization and maturation of >400 client proteins.
Brian S.J. Blagg, Kevin C. Catalfano
doaj   +1 more source

Heat shock protein 90 inhibition: rationale and clinical potential

Therapeutic Advances in Medical Oncology, 2012
Heat shock protein 90 (HSP90) is a molecular chaperone protein essential for cellular survival. Functionally, HSPs promote proper protein folding, prevent misfolding, and restore three-dimensional protein structure which is critical following toxic ...
Robert B. Den, Bo Lu
doaj   +1 more source

Holding but not folding: How a single charge flip uncouples the DNAJC7‐Hsp70 relay in amyotrophic lateral sclerosis

The FEBS Journal, EarlyView.
In this issue, Elmaleh et al. demonstrate that the E425K mutation in DNAJC7, associated with amyotrophic lateral sclerosis, selectively abolishes one of a co‐chaperone's dual functions. High‐resolution NMR confirmed that the mutation leaves the protein's structure intact while paralyzing its communication with the Hsp70 machinery.
Tsung‐Sheng Chiang, Jerome Boisbouvier, Lauren A. Gandy   +2 more
wiley   +1 more source

Insights into Hsp90 mechanism and in vivo functions learned from studies in the yeast, Saccharomyces cerevisiae

Frontiers in Molecular Biosciences
The molecular chaperone Hsp90 (Heat shock protein, 90 kDa) is an abundant and essential cytosolic protein required for the stability and/or folding of hundreds of client proteins.
Erick I. Rios, Isabel L. Hunsberger, Jill L. Johnson   +2 more
doaj   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, EarlyView.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Heat shock protein 90 (Hsp90) [PDF]

Science-Business eXchange, 2008
openaire   +3 more sources

Heat shock protein 90 (Hsp90) [PDF]

Science-Business eXchange, 2014
openaire   +2 more sources

HSP101‐encoding NEO‐TETRAPLOID RICE FERTILITY GENE 1 regulates tapetum development through interaction with SAPK2 in polyploid rice

Journal of Integrative Plant Biology, EarlyView.
In neo‐tetraploid rice, the NTRF1–SAPK2 heat shock protein–kinase module coordinates abscisic acid signaling with reactive oxygen species homeostasis to ensure timely tapetal programmed cell death and subsequent pollen maturation, providing a resource for the genetic improvement of polyploid rice.
Lichong Cao, Weicong Huang, Hang Yu, Sanglin Liu, Jianmin Yin, Zijun Lu, Jinwen Wu, Xiangdong Liu   +7 more
wiley   +1 more source

Evolvability of Chaperonin Substrate Proteins [PDF]

, 2009
Molecular chaperones ensure that their substrate proteins reach the functional native state, and prevent their aggregation. Recently, an additional function was proposed for molecular chaperones: they serve as buffers (_capacitors_) for evolution by ...
Emanuele Raineri, Luis Serrano, Paolo Ribeca, Tobias Maier   +3 more
core   +1 more source