Results 71 to 80 of about 21,325,054 (309)

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Seroepidemiology of Herpes Simplex Virus Type 1 and 2 in Northern Iran [PDF]

Iranian Journal of Public Health, 2012
Background: Herpes simplex virus (HSV) type 1 and 2 are common infectious agents worldwide. Data on prevalence of HSV-1 and HSV-2 infection are limited in Asia, especially in Iran.
S Rezaei-Chaparpordi, M Assmar, N Amirmozafari, L Modiri, A Massiha, S Shokri-Fashtali, Z Gholizadeh, S Akbari   +7 more
doaj   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling

mBio, 2019
TANK-binding kinase 1 (TBK1) is a key component of the antiviral immunity signaling pathway. It activates downstream interferon regulatory factor 3 (IRF3) and subsequent type I interferon (IFN-I) production.
Hongjuan You, Sisilia Zheng, Zhiming Huang, Yingying Lin, Qingtang Shen, Chunfu Zheng   +5 more
doaj   +1 more source

Lyotropic Liquid Crystal Precursor as an Innovative Herpes Simplex Virus Vector for Melanoma Therapy

Engineering Proceedings, 2022
To overcome the low-efficiency toxic side effects and high recurrence of traditional therapy for malignant melanoma, an in situ gel system, HSV-LLCP, was developed as a local treatment for malignant melanoma in this study.
Fangqin Fu, Wenhao Wang, Yukun Gu, Zhengwei Huang, Ying Huang, Xin Pan, Chuanbin Wu   +6 more
doaj   +1 more source

Pharmacomanipulation of HSV-1 induced chorioretinitis in mice [PDF]

Eye, 1997
In the von Szily mouse model, intracameral inoculation of herpes simplex virus type-1 (HSV-1) results in inflammation of the ipsilateral anterior segment with relative chorioretinal sparing and destructive contralateral chorioretinitis. We studied the effect of the systemic antiviral agent acyclovir (ACV) and anti-HSV-1 antibody therapy in this model ...
A, Merchant, J, Fletcher, C A, Medina, R K, Hemady, C S, Foster   +4 more
openaire   +2 more sources

Immunotherapeutical potential of DISC-HSV and OX40L in cancer

, 2004
Several vectors, viral and bacterial, have been developed over the past few years for means of generating an effective anti-tumor immune response. We have developed and studied a “model for immunotherapy” using a viral vector DISC-HSV, which efficiently ...
Robert C Rees, Selman A. Ali, Assudani, DP, Murrium Ahmad, Geng Li, Ahmad, M, Li, G, Deepak P. Assudani, Ali, SA, Rees, RC   +9 more
core   +1 more source

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development.

Frontiers in Cellular and Infection Microbiology, 2014
Interaction of Herpes Simplex Virus (HSV) glycoprotein D (gD) with the host cell surface during Chlamydia trachomatis/HSV co-infection stimulates chlamydiae to become persistent.
Jennifer Vanover Hall, Jennifer Vanover Hall, Jingru eSun, Jessica eSlade, Jessica eSlade, Jennifer eKintner, Marissa eBambino, Judy eWhittimore, Robert V. Schoborg, Robert V. Schoborg   +9 more
doaj   +1 more source

Seroprevalence of Herpes Simplex Virus Type 1 and 2 in Taiwan and Risk Factor Analysis, 2007. [PDF]

PLoS ONE, 2015
Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) are common human pathogens and might cause severe illness. Following primary infection, the viruses establish lifelong latent infection and are transmitted by close contact, both sexual and nonsexual ...
Jen-Hsiang Shen, Kuan-Ying Arthur Huang, Chen Chao-Yu, Chih-Jung Chen, Tzou-Yien Lin, Yhu-Chering Huang   +5 more
doaj   +1 more source