Results 91 to 100 of about 84,858 (261)

Dual biologic therapy in inflammatory bowel disease, a retrospective cohort study of vedolizumab and anti‐tumor necrosis factor alpha therapy in children

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Despite advances in pediatric inflammatory bowel disease (PIBD) with biologics, remission rates remain at 47%–60% with loss‐of‐response rates at 60%–68%. Evidence for efficacy of dual biologic therapy (DBT) with anti‐tumor necrosis factor alpha therapy (anti‐TNF‐α)‐ vedolizumab (VDZ) for children refractory to anti‐TNF‐α therapy is ...
Jonathan E. M. O'Donnell, Carlie Bolles, Claire R. Reilly, Manal Morgan, Christopher Burgess, Fariha Balouch, Peter J. Lewindon   +6 more
wiley   +1 more source

Image‐based and biochemical multimodal phenotyping for explainable classification of chia (Salvia hispanica L.) genotypes

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND This study developed an explainable machine learning framework integrating morphological, color, and biochemical characteristics for classifying chia (Salvia hispanica L.) genotypes. A dataset was assembled from 1200 seed images spanning four genotypes, from which 17 morphological and color features were extracted.
Sevim Akcura, Irem Poyraz, Beyza Ciftci, Mahmut Kaplan   +3 more
wiley   +1 more source

The order of infection shapes disease outcomes in influenza and herpes simplex virus coinfection by modulating immune responses

Virology Journal
Background Coinfections of influenza A virus (IAV) and herpes simplex virus type 1 (HSV-1) have been increasingly reported in patients with severe pneumonia, yet their pathogenesis remains poorly understood.
Yuanjun Lyu, Kailin Mai, Hongxuan Zhou, Chunguang Yang, Yunceng Weng, Zhenhui Zhang, Yang Wang, Zifeng Yang   +7 more
doaj   +1 more source

Image Vividness Changes due to White‐Boosting on WOLED Display

Journal of the Society for Information Display, EarlyView.
White‐Boosting is a display technique for RGBW WOLED panels that increases peak brightness. This study investigated its effect on perceived image vividness using paired‐comparison experiments. Across three psychophysical experiments, higher White‐Boosting consistently enhanced perceived vividness.
Woojae Jung, Youngshin Kwak, Myong Young Lee, Junghyun Ham   +3 more
wiley   +1 more source

Herpes simplex virus and kallikrein-related peptidases – a functional connection in Alzheimer‘s disease

Alzheimer’s Research & Therapy
Background The viral hypothesis of Alzheimer’s disease (AD) proposes that neurotropic pathogens may interact with amyloid and tau pathology, but the evidence remains controversial.
Oliver Goldhardt, Cinthia Mella Robles, Matthias Eberl, Tobias Dreyer, Antoninus Soosaipillai, Eleftherios P. Diamandis, Josef Priller, Dieter Hoffmann, Jochen M. Wettengel, Hianara Aracelly Bustamante, Paula Salazar, Markus Thaler, Carola Otth, Ingrid Pamela Ehrenfeld Slater, Timo Grimmer   +14 more
doaj   +1 more source

Juvenile Gangrenous Vasculitis of the Scrotum or Scrotum Lipschütz Ulcers

JEADV Clinical Practice, EarlyView.
ABSTRACT Lipschütz genital ulcers are traditionally described in adolescent females and often linked to acute viral infections. Their male counterpart remains poorly characterised. We report a 59‐year‐old man with sudden onset of unilateral necrotic ulcers on the scrotum and inguinal region following a brief febrile episode and mild pharyngitis ...
Francesco Bellinato, Paolo Gisondi, Giampiero Girolomoni   +2 more
wiley   +1 more source

Bevacizumab‐Associated Eczema Herpeticum in Metastatic Ovarian Carcinoma: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Eczema herpeticum (EH) is a rare but potentially life‐threatening cutaneous infection caused by herpes simplex virus (HSV), classically associated with atopic dermatitis. Its occurrence in oncology patients receiving anti‐angiogenic targeted therapy and cytotoxic chemotherapy is exceedingly uncommon.
Mandeep Dutta Joshi, Nishant Pandey, Sushan Ghimire, Avilasha Shah, Anurag Tiwari, Salina Subedi, Deepika Neupane   +6 more
wiley   +1 more source

Atypical Varicella‐Like Presentation of an Imported Mpox Case in Austria Confirmed to be Infected With Clade Ib

JEADV Clinical Practice, EarlyView.
ABSTRACT The recent upsurge of cases caused by the newly identified Clade Ib monkeypox virus (MPXV) in the Democratic Republic of the Congo and other countries has emerged as a significant public health concern. A 34‐year‐old male tourist from Venezuela presented in Vienna, Austria, during his travels through Europe with fever, pharyngitis and an ...
Amélie Hampel, David N. Springer, Jeremy V. Camp, Stephan W. Aberle, Maximilian Egg, Luigi Segagni Lusignani, Katharina Grabmeier‐Pfistershammer, Robert Strassl, Judith Wendt, Tamar Kinaciyan, Alessandra Handisurya   +10 more
wiley   +1 more source

The effect of cellular immune tolerance to HSV-1 antigens on the immunopathology of HSV-1 keratitis.

Investigative ophthalmology & visual science, 1989
Previous studies have revealed that herpes simplex virus type 1 (HSV-1) corneal stromal lesions do not develop in the absence of a cell-mediated immune (CMI) response to HSV-1 antigens. HSV-1 glycoprotein C (gC) has been shown to play an important role in the induction of the cytotoxic T lymphocyte (CTL) response to HSV-1 infections at anatomical sites
R L, Hendricks, R J, Epstein, T, Tumpey
openaire   +1 more source

Th2/Th17 Inflammation: Pathogenic Drivers and Therapeutic Targets in Darier and Hailey‐Hailey Diseases

JEADV Clinical Practice, EarlyView.
Skin samples of Hailey‐Hailey and Darier diseases were analyzed for inflammatory and barrier markers using indirect immunofluorescence and transcriptomic techniques. A mixed Th2/Th17 inflammatory pattern and altered expression of barrier markers were observed.
Ella Glodjajic, Darko Stojkov, Joanna Boros‐Majewska, Jeremy Di Domizio, Michel Gilliet, Christoph Schlapbach, Timothée Fettrelet, Luca Borradori, Hans‐Uwe Simon, Dagmar Simon, Susanne Radonjic‐Hoesli   +10 more
wiley   +1 more source