Results 81 to 90 of about 29,786,765 (312)

HSV-1 inflammasome activation in THP-1 cells is dependent on NLRP3, ASC, and caspase-1.

, 2020
A. THP-1 cells were stimulated overnight with PMA (100 ng/mL) and then incubated with HSV-1, nigericin and LPS (Ng+LPS), or media, as outlined in Materials and Methods, for 24 hours.
Andrew H. Karaba (2419798), Guido Massaccesi (8496237), Sara Botto (210516), Alexis Figueroa (8496234), Andrea L. Cox (8496243), Victor R. DeFilippis (8496240)   +5 more
core   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

تغییرات اپیدمیولوژیHSV-1: اثر آن بر روی وقوع هرپس چشمی [PDF]

Archives of Razi Institute, 2016
HSV-1 شیوع گسترده­ای در بین جمعیت­های انسانی دارد و نتیجه آن ایجاد طیف گسترده­ای از عفونت­ها و بیماری­ها می­باشد.اگرچه،HSV-2  عامل اصلی هرپس جنسی می­باشد، هرپس جنسی ناشی از HSV-1 نیز در حال افزایش می­باشد. این مقاله تغییرات اپیدمیولوژیکی HSV-1 را که شامل
بهمن عابدی کیاسری, زهره زارع توران پشتی   +1 more
doaj   +1 more source

HSV-1 activates inflammasomes in primary human macrophages.

, 2020
A and B. Primary human MDMs cultured without (M0 A) or with IFNγ (M1 B) were incubated with HSV-1 or media for 24 hours. Cell culture supernatants were collected and assayed for IL-18 (B represents the combination of two experiments).
Andrew H. Karaba (2419798), Guido Massaccesi (8496237), Sara Botto (210516), Alexis Figueroa (8496234), Andrea L. Cox (8496243), Victor R. DeFilippis (8496240)   +5 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Seroepidemiology of Herpes Simplex Virus Type 1 and 2 in Northern Iran [PDF]

Iranian Journal of Public Health, 2012
Background: Herpes simplex virus (HSV) type 1 and 2 are common infectious agents worldwide. Data on prevalence of HSV-1 and HSV-2 infection are limited in Asia, especially in Iran.
S Rezaei-Chaparpordi, M Assmar, N Amirmozafari, L Modiri, A Massiha, S Shokri-Fashtali, Z Gholizadeh, S Akbari   +7 more
doaj   +2 more sources

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling

mBio, 2019
TANK-binding kinase 1 (TBK1) is a key component of the antiviral immunity signaling pathway. It activates downstream interferon regulatory factor 3 (IRF3) and subsequent type I interferon (IFN-I) production.
Hongjuan You, Sisilia Zheng, Zhiming Huang, Yingying Lin, Qingtang Shen, Chunfu Zheng   +5 more
doaj   +1 more source

HSV-1 poly(A) site expression.

, 2017
(A) Heatmap of read counts (log2 scale) for predicted poly(A) sites corresponding to annotated poly(A) signals in the HSV-1 genome. Poly(A) sites are denoted by the corresponding gene name.
Caroline C. Friedel (29226), Thomas Bonfert (138970)   +1 more
core   +1 more source