Results 1 to 10 of about 78,152 (242)

Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine. [PDF]

JCI Insight
The skin at the site of HSV-2 reactivation is enriched for HSV-2-specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2-reactive CD4+ T cells from PBMCs by T cell receptor (TCR) β chain (TRB) sequencing before and after vaccination with a replication-incompetent ...
Ford ES, Li AZ, Laing KJ, Dong L, Diem K, Jing L, Mayer-Blackwell K, Basu K, Ott M, Tartaglia J, Gurunathan S, Reid JL, Ecsedi M, Chapuis AG, Huang ML, Magaret AS, Johnston C, Zhu J, Koelle DM, Corey L.   +19 more
europepmc   +3 more sources

Epidemiological Characteristics of HSV-1 and HSV-2 in 177,599 Patients Based on PCR Testing in South Korea (2018–2022) [PDF]

Pathogens
HSV-1 is associated with oral lesions and non-sexual transmission; HSV-2 is primarily transmitted through sexual contact and causes genital infections.
Hyeong Ho Kim, Sung Hun Jang, Jeong Su Han, Jae-Sik Jeon, Jae Kyung Kim   +4 more
doaj   +2 more sources

Analysis of HSV1/2 Infection Reveals an Association between HSV-2 Reactivation and Pregnancy [PDF]

Viruses
The herpes simplex viruses consist of the strains, HSV-1 and HSV-2, which are prevalent worldwide and lack a definitive cure. We aimed to explore the specific characteristics of HSV 1 and 2 infections, such as differences between gender assigned at birth,
Sara Dovrat, Adar Shabat, Anat Yahav-Dovrat, Zvia Soufiev, Ella Mendelson, Ela Kashi-Zagdoun, Galia Rahav   +6 more
doaj   +2 more sources

Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women. [PDF]

PLoS ONE, 2017
BACKGROUND:In the HIV-1 vaccine trial RV144, ALVAC-HIV prime with an AIDSVAX® B/E boost reduced HIV-1 acquisition by 31% at 42 months post first vaccination.
Peter B Gilbert, Jean-Louis Excler, Georgia D Tomaras, Lindsay N Carpp, Barton F Haynes, Hua-Xin Liao, David C Montefiori, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Gustavo H Kijak, Sodsai Tovanabutra, Donald P Francis, Carter Lee, Faruk Sinangil, Phillip W Berman, Nakorn Premsri, Prayura Kunasol, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Rhoda Morrow, Lawrence Corey, Jerome H Kim   +24 more
doaj   +5 more sources

Elsberg syndrome in HSV-2 infection

IDCases, 2023
Elsberg syndrome (ES) is a neuroinflammatory disease that causes acute or subacute lumbosacral radiculitis, with or without myelitis which accounts for approximately 5-10% of cauda equina syndrome and myelitis. We herein present a case of a middle-aged female who recently returned from the Dominican Republic and presented to the emergency room with ...
Omar Belfaqeeh, Alexandria Markley, Mudita Patel, Brian Markoff, Georgina Osorio   +4 more
openaire   +3 more sources

Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study

BMJ Open, 2023
Objectives To assess the seroprevalence of herpes simplex virus (HSV) types 1 and 2 in patients infected with HIV in Nigeria.Design Cross-sectional design from January to June 2019.Setting Federal Teaching Hospital, Ebonyi State, Nigeria.Participants A ...
Euslar Nnenna Onu, Uchechukwu Onyeukwu Ekuma, Hawraa K Judi, Ogbonnaya Ogbu, Nworie Okoro, Gloria C Ajugwo, Sousan Akrami, Chukwudum S Okoli, Chioma Ngozi Anyanwu, Morteza Saki, Peter Anyigor Edeh   +10 more
doaj   +1 more source

Fatal fulminant HSV-2 myocarditis: A complicated presentation [PDF]

International Journal of Infectious Diseases, 2022
Herpes simplex virus type 2 (HSV-2) infection is the leading cause of genital lesions. Infrequently HSV-2 primary infection can spread and involve other tissue and organs, however in immunocompetent individuals extra-genital complications are rare findings.
Daniele Colombo, Marco Albore, Franca Del Nonno, Giorgio Bolino, Mario D'Ambrosio, Alessandra Salvi, Camilla Cecannecchia, Laura Falasca   +7 more
openaire   +3 more sources

Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2. [PDF]

PLoS ONE, 2013
We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection against genital herpes.
William P Halford, Joshua Geltz, Edward Gershburg   +2 more
doaj   +1 more source

The Ticking CLOCK of HSV-2 Pathology [PDF]

Journal of Investigative Dermatology, 2018
Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs. Increased expression of the HSV-2 receptor Nectin-1 under the control of CLOCK coincided with an increase in viral titer suggesting that HSV-2 infection is ...
Bayliss, Rebecca J., Piguet, Vincent
openaire   +2 more sources

Immunization with Herpes Simplex Virus 2 (HSV-2) Genes plus Inactivated HSV-2 Is Highly Protective against Acute and Recurrent HSV-2 Disease [PDF]

Journal of Virology, 2011
ABSTRACTTo date, no vaccine that is safe and effective against herpes simplex virus 2 (HSV-2) disease has been licensed. In this study, we evaluated a DNA prime-formalin-inactivated-HSV-2 (FI-HSV2) boost vaccine approach in the guinea pig model of acute and recurrent HSV-2 genital disease.
Christopher S, Morello, Michael S, Levinson, Kimberly A, Kraynyak, Deborah H, Spector   +3 more
openaire   +2 more sources