Results 21 to 30 of about 78,152 (242)
Drug Delivery, 2021 Chitosan glutamate (gCS) spray-dried microparticles appear promising carriers to overcome challenges associated with vaginal microbicide delivery. This study aimed at elucidating the penetration and mucoadhesive behavior of developed gCS multiunit ...
Emilia Szymańska +6 more
doaj +1 more source
HSV-2 sacral radiculitis (Elsberg syndrome)
Neurology, 2004 A self-limiting syndrome of acute urinary retention in combination with variable other signs of spinal cord dysfunction and CSF pleocytosis was described by Elsberg >70 years ago.1 In many instances, a viral etiology is found, and herpes simplex virus type 2 (HSV-2) reactivation from spinal ganglia is the most common associated infection.
Eberhardt, O +3 more
openaire +3 more sources
Viruses, 2023 The thymidine kinase (TK) and DNA polymerase (pol) genes of the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are two important genes involved in antiviral resistance.
Jungwon Hyun +7 more
doaj +1 more source
Revista de Saúde Pública, 2010 OBJETIVO: Estimar a soroprevalência de anticorpos por vírus herpes simples (HSV-1 e HSV-2) e analisar fatores associados no Brasil. MÉTODOS: Estudo transversal realizado entre 1996 e 1997 em 1.090 indivíduos com idade entre um e 40 anos da população ...
Sue Ann Costa Clemens +1 more
doaj +1 more source
Vaginal HSV-2 Infection and Tissue Analysis [PDF]
BIO-PROTOCOL, 2017 The vaginal murine HSV-2 infection model is very useful in studying mucosal immunity against HSV-2 ( Overall et al., 1975 ; Renis et al., 1976 ; Parr and Parr, 2003). Histologically, the vagina of Depo-Provera-treated mice is lined by a single layer of mucus secreting columnar epithelial cells overlying two to three layers of proliferative cells.
Marie Iversen +2 more
openaire +3 more sources
Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.
PLoS ONE, 2015 Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0- mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity.
William P Halford +3 more
doaj +1 more source
Virus-specific immune memory at peripheral sites of herpes simplex virus type 2 (HSV-2) infection in guinea pigs. [PDF]
PLoS ONE, 2014 Despite its importance in modulating HSV-2 pathogenesis, the nature of tissue-resident immune memory to HSV-2 is not completely understood. We used genital HSV-2 infection of guinea pigs to assess the type and location of HSV-specific memory cells at ...
Jingya Xia +4 more
doaj +1 more source
PLoS ONE, 2010 Herpes simplex virus 1 (HSV-1) ICP0(-) mutants are interferon-sensitive, avirulent, and elicit protective immunity against HSV-1 (Virol J, 2006, 3:44).
William P Halford +2 more
doaj +1 more source
A herpes simplex virus 2 (HSV-2) glycoprotein D-expressing nonreplicating dominant-negative HSV-2 virus vaccine is superior to a gD2 subunit vaccine against HSV-2 genital infection in guinea pigs. [PDF]
PLoS ONE, 2014 We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response.
Pengwei Zhang +4 more
doaj +1 more source
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations
BMC Infectious Diseases, 2002 Background The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold
Leary Jeffry J +8 more
doaj +1 more source