Results 231 to 240 of about 10,923,960 (347)

Identification of ferroptosis hub gene cDKN1A relating to immune microenvironment in rheumatoid arthritis via bioinformatic analysis and experimental verification. [PDF]

Clin Rheumatol
Chen F, Tan F, Zou W, Liu J, Quan Z.
europepmc   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Lincoln Hub data and information architecture project: DATA²: Data architecture transforming access & analysis

, 2014
The vision for the DATA² project is to enable the intellectual capital produced by researchers and scientists in the Lincoln Hub to be better managed, curated and shared for reuse.
Carnaby, P, Staincliffe, P, Gibb, R, Cahalane, R, Sutherland, S, Laurenson, M, Charters, Stuart, McGlinchy, A   +7 more
core  

Bioinformatic validation of LCN2 as a common hub gene for ferroptosis, pyroptosis and necroptosis in ulcerative colitis. [PDF]

BMC Gastroenterol
Zhu N, Wang M, Wang M, Ren J.
europepmc   +1 more source

Data‐Driven Design of Self‐Adhesive Epidermal Electrodes and Sensors

Advanced Science, EarlyView.
This work presents self‐adhesive, stretchable epidermal electrodes and sensors developed through a data‐driven design framework that integrates artificial neural networks with genetic algorithms. By tailoring optimization objectives, either maximizing electrical conductivity and adhesion or enhancing piezoresistive sensitivity, the study enables the ...
Xuan Li, Shilei Wang, Milad Razbin, Danish Tahir, Chen Sang, Shuhua Peng, Markus Müllner, Wenlong Cheng, Wei Chen, Chun Hui Wang, Shuying Wu   +10 more
wiley   +1 more source

Identification of Hub Gene Characteristics and Immune Landscapes Across Aging Subtypes in Atherosclerosis: A Machine Learning-Based Multi-Omics Study With Experimental Verification. [PDF]

Chem Biol Drug Des
Fan Q, Chen K, Liu J, Diao X, Xia Z, Yu H, Zhu H.   +6 more
europepmc   +1 more source

Mitotic Hub Gene Network in Colorectal Cancer: Integrated Transcriptomic, Protein-Level, and Clinical-Genomic Characterization of a Ten-Gene Signature. [PDF]

Genes (Basel)
Kamal E, Moglad E, Mohager SO, Ahmed M, Aldoseri MM, Suwayyid BAA, Bawadood AS, Hamdan HZ, Akbulut M.   +8 more
europepmc   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Integrated multi-omics profiling of the early post-infarct heart reveals a hub gene network associated with myeloid-driven inflammation. [PDF]

Front Cardiovasc Med
Wang Z, Shi J, Lai Y, Wang S.
europepmc   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source