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Association analysis of hepatocellular carcinoma‐related hub proteins and hub genes
PROTEOMICS – Clinical Applications, 2023AbstractPurposeHepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The occurrence and development of HCC are closely related to epigenetic modifications. Epigenetic modifications can regulate gene expression and related functions through DNA methylation.
Xinhong Zhang +3 more
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RANKING DIFFERENTIAL HUBS IN GENE CO-EXPRESSION NETWORKS
Journal of Bioinformatics and Computational Biology, 2012Identifying the genes that change their expressions between two conditions (such as normal versus cancer) is a crucial task that can help in understanding the causes of diseases. Differential networking has emerged as a powerful approach to detect the changes in network structures and to identify the differentially connected genes among two networks ...
Omar Odibat, Chandan K. Reddy
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Spatial organization of gene expression: the active chromatin hub
Chromosome Research, 2003Developmental and tissue-specific expression of higher eukaryotic genes involves activation of transcription at the appropriate time and place and keeping it silent otherwise. Unlike housekeeping genes, tissue-specific genes generally do not cluster on the chromosomes.
de Laat, WL (Wouter), Grosveld, Frank
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Identification of Potential Hub Genes in Alopecia Areata
Experimental DermatologyABSTRACT Alopecia areata (AA) is an immune‐mediated chronic alopecia disease, but its specific pathogenesis is unclear. Gene expression data for AA patients (AAs) and healthy controls (HCs) were retrieved from the GEO database, and the differentially expressed genes (DEGs) between AAs and HCs were identified.
Runqiu Liu +7 more
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Identifying Hub Genes Associated with Sex Disparities in Prolactinomas
Genetic Testing and Molecular BiomarkersBackground: Male patients with prolactinomas exhibit greater invasiveness, resistance to dopamine agonists, making treatment more challenging. This study aims to explore the potential different genes contributing to sex disparities in prolactinomas ...
Yuan Zhang +5 more
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Unveiling the Hub Genes Involved in Cadmium-Induced Hepatotoxicity
Biological Trace Element ResearchCadmium (Cd) is a highly toxic heavy metal that can cause severe liver damage in both humans and animals. However, the specific genes responsible for Cd-induced hepatotoxicity are still not fully understood. Therefore, the aim of this study was to identify the key genes associated with Cd-induced liver damage.
Bing, Yang +3 more
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